trimethadione

Also known as Tridione®, Troxidone, Trimethadion, Triméthadione, Trimethadionum, Trimethinum

Trimethadione (Tridione) is an oxazolidinedione anticonvulsant. It is most commonly used to treat epileptic conditions that are resistant to other treatments.

Research

619 papers

Antiepileptic drug mechanisms of action.Epilepsia · 1995
[Fetal trimethadione syndrome].Ryoikibetsu shokogun shirizu · 2001
[Fetal trimethadione effects].Ryoikibetsu shokogun shirizu · 2000
Trimethadione (tridione) nephrosis.A.M.A. journal of diseases of children · 1959
The fetal trimethadione syndrome.The Journal of pediatrics · 1975

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Wikidata facts

Subclass of: chemical compound
Mass: 143.058243
Has use: medication

Show 7 more facts

chemical formula: C₆H₉NO₃
medical condition treated: childhood absence epilepsy
canonical SMILES: CC1(C(=O)N(C(=O)O1)C)C
Commons category: Trimethadione
defined daily dose: 1.5
melting point: 47
has characteristic: bitterness

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Encyclopedic overview

3 sections

Contents

Fetal trimethadione syndrome
References
External links

Trimethadione (Tridione) is an oxazolidinedione anticonvulsant. It is most commonly used to treat epileptic conditions that are resistant to other treatments.

It is primarily effective in treating absence seizures, but can also be used in refractory temporal lobe epilepsy. It is usually administered 3 or 4 times daily, with the total daily dose ranging from 900 mg to 2.4 g. Treatment is most effective when the concentration of its active metabolite, dimethadione, is above 700 μg/mL. Severe adverse reactions are possible, including Steven Johnson syndrome, nephrotoxicity, hepatitis, aplastic anemia, neutropenia, or agranulocytosis. More common adverse effects include drowsiness, hemeralopia, and hiccups.

Excerpted from Wikipedia’s “trimethadione” article, available under the CC BY-SA 4.0 licence.

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