UBE4B
Sign in to saveAlso known as E4, HDNB1, UBOX3, UFD2, UFD2A, ubiquitination factor E4B
Ubiquitin conjugation factor E4 B is a protein that in humans is encoded by the UBE4B gene.
In the Vinony graph
Vinony's link graph records 4 inbound references to UBE4B, and connects out to PubMed, human chromosome 1 and Ensembl genome database project.
It is catalogued under the topic Genes on human chromosome 1.
Vinony links it to 6 Wikipedia language editions.
Gene data
UBE4B- Name
- ubiquitination factor E4B
- Type
- protein-coding
- Position
- 10,032,832–10,181,244 (+)
- Aliases
- E4, HDNB1, UBOX3, UFD2, UFD2A
- Ensembl
- ENSG00000130939
- RefSeq RNA
- NM_001105562.3, NM_001410744.1, NM_006048.5, XM_011540488.4, XM_011540489.4
- RefSeq protein
- NP_001099032.1, NP_001397673.1, NP_006039.2, XP_011538790.1, XP_011538791.1
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes an additional conjugation factor, E4, which is involved in multiubiquitin chain assembly. This gene is also the strongest candidate in the neuroblastoma tumor suppressor genes. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
ubiquitination factor E4B
- Symbol
- UBE4B
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 1:10,032,832-10,181,244
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein UBE4B PDB 2KRE.png
Show 7 more facts
- HomoloGene ID
- 107623
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/10277
- genomic end
- 10241297
- genomic start
- 10092890
- chromosome
- human chromosome 1
- cytogenetic location
- 1p36.22
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
3 sectionsContents
- References
- Further reading
- External links
Ubiquitin conjugation factor E4 B is a protein that in humans is encoded by the UBE4B gene.
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s.
Excerpted from Wikipedia’s “UBE4B” article, available under the CC BY-SA 4.0 licence.