UBE4B
Sign in to saveAlso known as E4, HDNB1, UBOX3, UFD2, UFD2A, ubiquitination factor E4B
Ubiquitin conjugation factor E4 B is a protein that in humans is encoded by the UBE4B gene.
Gene data
UBE4B- Name
- ubiquitination factor E4B
- Type
- protein-coding
- Position
- 10,032,832–10,181,244 (+)
- Aliases
- E4, HDNB1, UBOX3, UFD2, UFD2A
- Ensembl
- ENSG00000130939
- RefSeq RNA
- NM_001105562.3, NM_001410744.1, NM_006048.5, XM_011540488.4, XM_011540489.4
- RefSeq protein
- NP_001099032.1, NP_001397673.1, NP_006039.2, XP_011538790.1, XP_011538791.1
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes an additional conjugation factor, E4, which is involved in multiubiquitin chain assembly. This gene is also the strongest candidate in the neuroblastoma tumor suppressor genes. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Wikidata facts
- Image
- Protein UBE4B PDB 2KRE.png
Show 5 more facts
- HomoloGene ID
- 107623
- exact match
- identifiers.org/ncbigene/10277
- genomic end
- 10241297
- genomic start
- 10092890
- cytogenetic location
- 1p36.22
Sources (4)
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- References
- Further reading
- External links
Ubiquitin conjugation factor E4 B is a protein that in humans is encoded by the UBE4B gene.
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s.