ZNF346
Sign in to saveAlso known as JAZ, Zfp346, zinc finger protein 346
Zinc finger protein 346 is a protein that in humans is encoded by the ZNF346 gene.
In the Vinony graph
Vinony's link graph records 811 inbound references to ZNF346, and connects out to PubMed, human chromosome 5 and homeobox.
Vinony files it under Genes on human chromosome 5 and Transcription factors.
Vinony links it to 5 Wikipedia language editions.
Gene data
ZNF346- Name
- zinc finger protein 346
- Type
- protein-coding
- Position
- 177,022,059–177,081,202 (+)
- Aliases
- JAZ, Zfp346
- Ensembl
- ENSG00000113761
- RefSeq RNA
- NM_001308213.2, NM_001308214.2, NM_001308215.2, NM_001308216.2, NM_001308218.2
- RefSeq protein
- NP_001295142.1, NP_001295143.1, NP_001295144.1, NP_001295145.1, NP_001295147.1
The protein encoded by this gene is a nucleolar, zinc finger protein that preferentially binds to double-stranded (ds) RNA or RNA/DNA hybrids, rather than DNA alone. Mutational studies indicate that the zinc finger domains are not only essential for dsRNA binding, but are also required for its nucleolar localization. The encoded protein may be involved in cell growth and survival. It plays a role in protecting neurons by inhibiting cell cycle re-entry via stimulation of p21 gene expression. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2015].
Gene Ontology
Molecular function
via MyGene.info
Gene · Ensembl
zinc finger protein 346
- Symbol
- ZNF346
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 5:177,022,059-177,081,202
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 8 more facts
- HomoloGene ID
- 8073
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/23567
- genomic end
- 176508190
- genomic start
- 176449697
- expressed in
- tibialis anterior muscle
- chromosome
- human chromosome 5
- cytogenetic location
- 5q35.2
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
3 sectionsContents
- References
- Further reading
- External links
Zinc finger protein 346 is a protein that in humans is encoded by the ZNF346 gene.
The protein encoded by this gene is a nucleolar, zinc finger protein that preferentially binds to double-stranded (ds) RNA or RNA/DNA hybrids, rather than DNA alone. Mutational studies indicate that the zinc finger domains are not only essential for dsRNA binding, but are also required for its nucleolar localization. The encoded protein may be involved in cell growth and survival.
Excerpted from Wikipedia’s “ZNF346” article, available under the CC BY-SA 4.0 licence.