Genes on human chromosome 14

Fermitin family homolog 2 (FERMT2) also known as pleckstrin homology domain-containing family C member 1 (PLEKHC1) or kindlin-2 is a protein that in humans is encoded by the FERMT2 gene.

Nesprin-2 is a protein that in humans is encoded by the SYNE2 gene. The human SYNE2 gene consists of 116 exons and encodes nesprin-2, a member of the nuclear envelope (NE) spectrin-repeat (nesprin) family. Nesprins are modular proteins with a central extended spectrin-repeat (SR) rod domain and a C-terminal Klarsicht/ANC-1/Syne homology (KASH) transmembrane domain, which acts as a NE-targeting motif. Nesprin-2 (Nesp2) binds to cytoplasmic F-actin, tethering the nucleus to the cytoskeleton and maintaining the structural integrity of the nucleus.

protein family

protein family

Ribonuclease A family member k6 is a protein that in humans is encoded by the RNASE6 gene.

Retinol dehydrogenase 11 is an enzyme that in humans is encoded by the RDH11 gene.

protein-coding gene in the species Homo sapiens

Sal-like protein 2 is a protein that in humans is encoded by the SALL2 gene.

Cutaneous T-cell lymphoma-associated antigen 5 is a protein that in humans is encoded by the CTAGE5 gene.

Forkhead box protein G1 is a protein that in humans is encoded by the FOXG1 gene.

Forkhead box protein N3 is a protein that in humans is encoded by the FOXN3 gene.

A-kinase anchor protein 5 is a protein that in humans is encoded by the AKAP5 gene.

FERM domain-containing protein 6 is a protein that in humans is encoded by the FRMD6 gene.

Zinc finger protein 219 is a protein that in humans is encoded by the ZNF219 gene.

Signal-induced proliferation-associated 1-like protein 1 is a protein that in humans is encoded by the SIPA1L1 gene.

Ninein is a protein that in humans is encoded by the NIN gene.

Golgin subfamily A member 5 is a protein that in humans is encoded by the GOLGA5 gene.

Proteasome activator complex subunit 2 is a protein that in humans is encoded by the PSME2 gene.

Protein NDRG2 is a protein that in humans is encoded by the NDRG2 gene (NMYC downstream-regulated gene 2).

Nuclear factor of activated T-cells, cytoplasmic 4 is a protein that in humans is encoded by the NFATC4 gene.

Mediator of RNA polymerase II transcription subunit 6 is one of the subunits of the Mediator complex. It is an enzyme that in humans is encoded by the MED6 gene.

ATP-dependent RNA helicase DDX24 is an enzyme that in humans is encoded by the DDX24 gene.

Exocyst complex component 5 is a protein that in humans is encoded by the EXOC5 gene.

Pleckstrins are a family of proteins found in platelets and other cells. The name derives from platelet and leukocyte C kinase substrate and the KSTR string of amino acids. The prototype protein, now called pleckstrin-1, was first identified in 1979 as the major substrate of protein kinase C in platelets. The homolog pleckstrin-2 is more widely expressed in tissues.

RING finger protein 31 is a protein that in humans is encoded by the RNF31 gene.

Zinc finger, FYVE domain containing 26 is a protein that in humans is encoded by the ZFYVE26 gene.

Olfactory receptor 4K17 is a protein that in humans is encoded by the OR4K17 gene.

Legumain is a protein that in humans is encoded by the LGMN gene.

Reticulon-1 also known as neuroendocrine-specific protein (NSP) is a protein that in humans is encoded by the RTN1 gene.

Glutaredoxin 5, also known as GLRX5, is a protein which in humans is encoded by the GLRX5 gene located on chromosome 14. This gene encodes a mitochondrial protein, which is evolutionarily conserved. It is involved in the biogenesis of iron- sulfur clusters, which are required for normal iron homeostasis. Mutations in this gene are associated with autosomal recessive pyridoxine-refractory sideroblastic anemia.

N6-adenosine-methyltransferase 70 kDa subunit (METTL3) is an enzyme that in humans is encoded by the METTL3 gene. METTL3 is located on the human chromosome 14q11.2 (Cancer Biology) and out of the METTL protein family, it is the most studied.

Ubiquitin thioesterase OTUB2 is an enzyme that in humans is encoded by the OTUB2 gene.

Fibronectin leucine-rich repeat transmembrane protein FLRT2 is a protein that in humans is encoded by the FLRT2 gene.

Tandem C2 domains nuclear protein is a protein that in humans is encoded by the TC2N gene.

Thiamine-triphosphatase is an enzyme involved in thiamine metabolism. It catalyzes the chemical reaction

TERF1-interacting nuclear factor 2 is a protein that in humans is encoded by the TINF2 gene. TINF2 is a component of the shelterin protein complex found at the end of telomeres.

Splicing factor, arginine/serine-rich 5 is a protein that in humans is encoded by the SFRS5 gene.

Ribosomal protein S6 kinase alpha-5 is an enzyme that in humans is encoded by the RPS6KA5 gene. This kinase, together with RPS6KA4, are thought to mediate the phosphorylation of histone H3, linked to the expression of immediate early genes.

Atlastin-1, is a protein that in humans is encoded by the ATL1 gene.

Copine-6 is a protein that in humans is encoded by the CPNE6 gene.

Fibulin-5 (also known as DANCE (developmental arteries and neural crest epidermal growth factor (EGF)-like)) is a protein that in humans is encoded by the FBLN5 gene.

Probable O-sialoglycoprotein endopeptidase is an enzyme in humans encoded by the OSGEP gene.

Olfactory receptor 10G3 is a protein that in humans is encoded by the OR10G3 gene.

Kinectin is a protein that in humans is encoded by the KTN1 gene.

Protein sel-1 homolog 1 is a protein that in humans is encoded by the SEL1L gene.

NPAS3 or Neuronal PAS domain protein 3 is a brain-enriched transcription factor belonging to the bHLH-PAS superfamily of transcription factors, the members of which carry out diverse functions, including circadian oscillations, neurogenesis, toxin metabolism, hypoxia, and tracheal development. NPAS3 contains a basic helix-loop-helix structural motif and two PAS domain, like the other proteins in the superfamily.

Rho-related GTP-binding protein RhoJ is a protein that in humans is encoded by the RHOJ gene.