Also known as 2-amino purine, 2'-amino-purine, 1H-purin-2-amine
2-Aminopurine (2AP), a purine analog of guanine and adenine, is a fluorescent molecular marker used in nucleic acid research. It most commonly pairs with thymine as an adenine-analogue. It uses a different ketone oxygen on thymine for H-bonding and forms a stronger bond.
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2-Aminopurine (2AP), a purine analog of guanine and adenine, is a fluorescent molecular marker used in nucleic acid research. It most commonly pairs with thymine as an adenine-analogue. It uses a different ketone oxygen on thymine for H-bonding and forms a stronger bond.
It can also pair with cytosine at low pH in a protonated way like a functional analogue of guanine. For this reason it is sometimes used in the laboratory for mutagenesis. A mixture of structures are present according to NMR. An atomic-resolution structures of the 2AP·C pair has been produced.
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Discovered by embedding cosine similarity (sentence-transformers MiniLM, 384-dim).