2-Thiouracil

Also known as 2-Thio-2,4-(1H,3H)-pyrimidinedione, 2-Thioxo-2,3-dihydro-1H-pyrimidin-4-one, 2-mercapto-4-pyrimidinol, 4-Hydroxy-2-pyrimidinethiol

2-Thiouracil is a chemical derivative of uracil in which the oxygen atom in the 2-position of the ring is substituted by sulfur. It is classified as a thiourea.

Chemical data

Formula: C4H4N2OS
Molecular weight: 128.15 g/mol
IUPAC name: 2-sulfanylidene-1H-pyrimidin-4-one

via PubChem

Drug data · ChEMBL

Molecule type: Small molecule

via ChEMBL · EBI

Wikidata facts

Mass: 128.004

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canonical SMILES: C1=CNC(=S)NC1=O
chemical formula: C₄H₄N₂OS

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Medical use
References

2-Thiouracil is a chemical derivative of uracil in which the oxygen atom in the 2-position of the ring is substituted by sulfur. It is classified as a thiourea.

== Medical use == The substance is a historically relevant anti-thyroid preparation. Edwin Astwood used it in 1943 as therapy for Graves' disease for the first time.