English

English Deutsch Español Français Italiano Nederlands Português Svenska

GeneQ17832633· pop 7· linked from 819 articles

ATF3

Sign in to save

Also known as activating transcription factor 3

Cyclic AMP-dependent transcription factor ATF-3 is a protein that, in humans, is encoded by the ATF3 gene.

Gene data

ATF3

Name: activating transcription factor 3
Type: protein-coding
Position: 212,565,334–212,620,777 (+)
Ensembl: ENSG00000162772
RefSeq RNA: NM_001030287.4, NM_001040619.3, NM_001206484.3, NM_001206485.1, NM_001206486.2
RefSeq protein: NP_001025458.1, NP_001035709.1, NP_001193413.2, NP_001193415.1, NP_001193417.2

This gene encodes a member of the mammalian activation transcription factor/cAMP responsive element-binding (CREB) protein family of transcription factors. This gene is induced by a variety of signals, including many of those encountered by cancer cells, and is involved in the complex process of cellular stress response. Multiple transcript variants encoding different isoforms have been found for this gene. It is possible that alternative splicing of this gene may be physiologically important in the regulation of target genes. [provided by RefSeq, Apr 2011].

Gene Ontology

Biological process

negative regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II regulation of DNA-templated transcription regulation of transcription by RNA polymerase II regulation of transcription by RNA polymerase II regulation of transcription by RNA polymerase II regulation of transcription by RNA polymerase II

Molecular function

transcription cis-regulatory region binding RNA polymerase II transcription regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific

Cellular component

chromatin nucleus nucleus nucleus nucleus nucleoplasm nucleoplasm nucleolus

Pathways

Adaptive Immune System Immune System Cellular responses to stress Cellular responses to stress ATF4 activates genes in response to endoplasmic reticulum stress PERK regulates gene expression Unfolded Protein Response (UPR)Regulation of T cell activation by CD28 family Co-inhibition by PD-1 Cellular responses to stimuli

via MyGene.info

Wikidata facts

Show 5 more facts

HomoloGene ID: 1265
exact match: identifiers.org/ncbigene/467
genomic end: 212794119
genomic start: 212738676
cytogenetic location: 1q32.3

Sources (6)

via Wikidata · CC0

~2 min read

Article

7 sections

Contents

Function
Clinical significance
See also
Interactions
References
Further reading
External links

Cyclic AMP-dependent transcription factor ATF-3 is a protein that, in humans, is encoded by the ATF3 gene.

== Function ==

Available in 7 languages

via Wikidata sitelinks · CC0

Categories

Genes on human chromosome 1 Transcription factors