Structure via PubChem · Public domain (PubChem)
bitolterol
Sign in to saveAlso known as Bitolterol Mesylate, Bitolterolum, 4-[2-(tert-butylamino)-1-hydroxyethyl]-o-phenylene di-p-toluate, bis(4-methylbenzoic acid) 4-[2-(tert-butylamino)-1-hydroxyethyl]-1,2-phenylene ester, 4-(2-(tert-butylamino)-1-hydroxyethyl)-o-phenylene di-p-toluate
Bitolterol mesylate, formerly sold under the brand name Tornalate, is a short-acting β2-adrenergic receptor agonist used for the relief of bronchospasm in conditions such as asthma and chronic obstructive pulmonary disease (COPD). Bitolterol relaxes the smooth muscles present continuously around the bronchi and bronchioles facilitating the flow of air through them.
Chemical data
- Formula
- C28H31NO5
- Molecular weight
- 461.5 g/mol
- IUPAC name
- [4-[2-(tert-butylamino)-1-hydroxyethyl]-2-(4-methylbenzoyl)oxyphenyl] 4-methylbenzoate
- SMILES
- CC1=CC=C(C=C1)C(=O)OC2=C(C=C(C=C2)C(CNC(C)(C)C)O)OC(=O)C3=CC=C(C=C3)C
- InChIKey
- FZGVEKPRDOIXJY-UHFFFAOYSA-N
- XLogP
- 5.2
- Polar surface area
- 84.9 Ų
- H-bond donors
- 2
- H-bond acceptors
- 6
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 1984
- Admin. routes
- topical
- Indications
- Airway obstruction
via ChEMBL · EBI
Research
47 papers- Bitolterol.2006
- Bitolterol. A preliminary review of its pharmacological properties and therapeutic efficacy in reversible obstructive airways disease.Drugs · 1988
- Bitolterol mesylate: a beta-adrenergic agent. Chemistry, pharmacokinetics, pharmacodynamics, adverse effects and clinical efficacy in asthma.Pharmacotherapy · 1985
- Beta-2 Adrenergic Agonists.2012
- Bitolterol--a new bronchodilator.The Medical letter on drugs and therapeutics · 1985
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 461.220223
- Has use
- medication
Show 6 more facts
- chemical formula
- C₂₈H₃₁NO₅
- medical condition treated
- asthma
- canonical SMILES
- CC1=CC=C(C=C1)C(=O)OC2=C(C=C(C=C2)C(CNC(C)(C)C)O)OC(=O)C3=CC=C(C=C3)C
- World Health Organisation international non-proprietary name
- bitolterol
- subject has role
- bronchodilator
- Commons category
- Bitolterol
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
1 sectionsContents
- References
Bitolterol mesylate, formerly sold under the brand name Tornalate, is a short-acting β2-adrenergic receptor agonist used for the relief of bronchospasm in conditions such as asthma and chronic obstructive pulmonary disease (COPD). Bitolterol relaxes the smooth muscles present continuously around the bronchi and bronchioles facilitating the flow of air through them.
225px|thumb|left|class=skin-invert-image|Colterol
Excerpted from Wikipedia’s “bitolterol” article, available under the CC BY-SA 4.0 licence.
Gallery (2)
Available in 9 languages
via Wikidata sitelinks · CC0