carmofur

Carmofur (INN) or HCFU (1-hexylcarbamoyl-5-fluorouracil) is a pyrimidine analogue used as an antineoplastic agent. It is a derivative of fluorouracil, being a lipophilic-masked analog of 5-FU that can be administered orally.

Research

299 papers

Versatile use of Carmofur: A comprehensive review of its chemistry and pharmacology.Drug development research · 2022
Carmofur Exhibits Antimicrobial Activity Against Streptococcus pneumoniae.Antibiotics (Basel, Switzerland) · 2025
Carmofur prevents cell cycle progression by reducing E2F8 transcription in temozolomide-resistant glioblastoma cells.Cell death discovery · 2023
Temperature/pH-responsive carmofur-loaded nanogels rapidly prepared via one-pot laser-induced emulsion polymerization.Colloids and surfaces. B, Biointerfaces · 2022
Structural basis of main proteases of MERS-CoV bound to antineoplastic drug carmofur.Biochemical and biophysical research communications · 2024

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Wikidata facts

Mass: 257.118

Show 2 more facts

chemical formula: C₁₁H₁₆FN₃O₃
canonical SMILES: CCCCCCNC(=O)N1C=C(C(=O)NC1=O)F

Sources (2)

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Article

6 sections

Contents

Biology
Mechanism of action
Medicinal uses
Adverse effects
Chemical synthesis
References

==Biology== Carmofur prodrug is ingested and taken up in the intestine, overcoming the problem of 5-FU degradation by dihydropyrimidine dehydrogenase. Once inside a cell, the carmofur prodrug is converted into 5-FU.