cefotiam

Also known as (6R,7R)-7-[2-(2-Amino-thiazol-4-yl)-acetylamino]-3-[1-(2-dimethylamino-ethyl)-1H-tetrazol-5-ylsulfanylmethyl]-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid, CTM, Cefotiamum

Cefotiam is a parenteral third-generation cephalosporin antibiotic. It has broad-spectrum activity against Gram-positive and Gram-negative bacteria. As a beta-lactam, its bactericidal activity results from the inhibition of cell wall synthesis via affinity for penicillin-binding proteins.

Research

723 papers

Cefotiam hexetil.International journal of antimicrobial agents · 1995
Clinical pharmacokinetics of cefotiam.Clinical pharmacokinetics · 1989
Cefotiam Treatment in Children: Evidence of Subtherapeutic Levels.Therapeutic drug monitoring · 2020
Study on Isomeric Impurities in Cefotiam Hydrochloride.Frontiers in chemistry · 2020
Cefotiam-induced IgE-mediated occupational contact anaphylaxis of nurses; case reports, RAST analysis, and a review of the literature.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 1994

via PubMed

Wikidata facts

Mass: 525.104

Show 5 more facts

chemical formula: C₁₈H₂₃N₉O₄S₃
Commons category: Cefotiam
isomeric SMILES: CN(C)CCN1C(=NN=N1)SCC2=C(N3[C@@H]([C@@H](C3=O)NC(=O)CC4=CSC(=N4)N)SC2)C(=O)O
canonical SMILES: CN(C)CCN1C(=NN=N1)SCC2=C(N3C(C(C3=O)NC(=O)CC4=CSC(=N4)N)SC2)C(=O)O
World Health Organisation international non-proprietary name: cefotiam

Sources (4)

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Article

7 sections

Contents

Medical uses
Dosage
Spectrum of bacterial susceptibility
Adverse effects
Mechanism of action
References
Further reading

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