Structure via PubChem · Public domain (PubChem)
chlorcyclizine
Sign in to saveAlso known as Chlorcyclizin, Chlorcyclizinum, Clorciclizina
Chlorcyclizine (Di-Paralene, Mantadil, Pruresidine, Trihistan) is a first-generation antihistamine of the diphenylmethylpiperazine group marketed in the United States and certain other countries. It is used primarily to treat allergy symptoms such as rhinitis, urticaria, and pruritus, and may also be used as an antiemetic. In addition to its antihistamine effects, chlorcyclizine has some anticholinergic, antiserotonergic, and local anesthetic properties. It has been studied as a potential treatment for various flaviviruses like hepatitis C and Zika virus.
Chemical data
- Formula
- C18H21ClN2
- Molecular weight
- 300.8 g/mol
- IUPAC name
- 1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine
- SMILES
- CN1CCN(CC1)C(C2=CC=CC=C2)C3=CC=C(C=C3)Cl
- InChIKey
- WFNAKBGANONZEQ-UHFFFAOYSA-N
- XLogP
- 4.5
- Polar surface area
- 6.5 Ų
- H-bond donors
- 0
- H-bond acceptors
- 2
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
- Indications
- allergic disease
via ChEMBL · EBI
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 300.139
- Has use
- medication
Show 6 more facts
- Commons category
- Chlorcyclizine
- chemical formula
- C₁₈H₂₁ClN₂
- medical condition treated
- allergic rhinitis
- canonical SMILES
- CN1CCN(CC1)C(C2=CC=CC=C2)C3=CC=C(C=C3)Cl
- defined daily dose
- 0.1
- subject has role
- H1 antagonist
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- See also
- References
Chlorcyclizine (Di-Paralene, Mantadil, Pruresidine, Trihistan) is a first-generation antihistamine of the diphenylmethylpiperazine group marketed in the United States and certain other countries. It is used primarily to treat allergy symptoms such as rhinitis, urticaria, and pruritus, and may also be used as an antiemetic. In addition to its antihistamine effects, chlorcyclizine has some anticholinergic, antiserotonergic, and local anesthetic properties. It has been studied as a potential treatment for various flaviviruses like hepatitis C and Zika virus.
== See also == Cyclizine Homochlorcyclizine Meclizine
Excerpted from Wikipedia’s “chlorcyclizine” article, available under the CC BY-SA 4.0 licence.