EntityQ407781· pop 43· linked from 1,873 articles

dextromethorphan

Dextromethorphan is a cough suppressant used in many cough and cold medicines. In 2022, the US Food and Drug Administration (FDA) approved the combination dextromethorphan/bupropion to serve as a rapid-acting antidepressant in people with major depressive disorder.

Key facts

Drug.Verifiedfields: changed
Drug.Watchedfields: changed
Drug.verifiedrevid: 470624518
Drug.image: Dextromethorphan-2D-Skeletal-Chemical-Formula.png
Drug.image_class: skin-invert-image
Drug.width: 300
Drug.image2: Dextromethorphan-3D-Ball-And-Stick-Model.png
Drug.image_class2: bg-transparent
Drug.width2: 234
Drug.tradename: Delsym, others
Drug.MedlinePlus: a682492
Drug.DailyMedID: Dextromethorphan
Drug.pregnancy_AU: A
Drug.addiction_liability: Low–moderate
Drug.routes_of_administration: By mouth
Drug.class: Antitussive;Serotonin–norepinephrine reuptake inhibitor; NMDA receptor antagonist; Dissociative hallucinogen
Drug.ATC_prefix: R05
Drug.ATC_suffix: DA09

via Wikipedia infobox

Article

25 sections

Contents

Medical uses
Cough suppression
Pseudobulbar affect
Major depressive disorder
Adverse effects
Neurotoxicity
Dependence and withdrawal
Interactions
Pharmacology
Pharmacodynamics
Pharmacokinetics
Metabolism
Chemistry
Synthesis
Racemate separation
Traditional synthesis
Grewe's cyclization
Improved Grewe's cyclization
History
Society and culture
Marketing
Recreational use
Research
References
External links

It is in the morphinan class of medications with dissociative and stimulant properties (at lower doses). Dextromethorphan does not have a significant affinity for the mu-opioid receptor activity typical of morphinan compounds and exerts its therapeutic effects through several other receptors. In its pure form, dextromethorphan occurs as a white powder.