diacerein
Sign in to saveDiacerein (INN), also known as diacetylrhein, is a slow-acting medicine of the class anthraquinone used to treat joint diseases such as osteoarthritis. It works by inhibiting interleukin-1 beta. An updated 2014 Cochrane review found diacerein had a small beneficial effect on pain. Diacerein-containing medications are registered in some European Union and Asian countries and included as a treatment option on several international therapeutic guidelines.
Research
491 papers- Diacerein.Drugs · 1997
- Diacerein for osteoarthritis.The Cochrane database of systematic reviews · 2014
- Diacerein: Recent insight into pharmacological activities and molecular pathways.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2020
- Diacerein for osteoarthritis.The Cochrane database of systematic reviews · 2006
- [Diacerein].Annali italiani di medicina interna : organo ufficiale della Societa italiana di medicina interna · 1986
via PubMed
~4 min read
Encyclopedic overview
7 sectionsContents
- Synthesis
- Pharmacology
- Side effects
- Special warning
- Dosage and administration
- See also
- References
Diacerein (INN), also known as diacetylrhein, is a slow-acting medicine of the class anthraquinone used to treat joint diseases such as osteoarthritis. It works by inhibiting interleukin-1 beta. An updated 2014 Cochrane review found diacerein had a small beneficial effect on pain. Diacerein-containing medications are registered in some European Union and Asian countries and included as a treatment option on several international therapeutic guidelines.
==Synthesis== Various synthetic routes to diacerein have been developed, most of which utilize aloin as a precursor. The hydroxyl groups of aloin are acetylated, and the intermediates are subsequently oxidized using chromic anhydride in an acetic acid solvent system..
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