Structure via PubChem · Public domain (PubChem)
dibenzepin
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Dibenzepin, sold under the brand name Noveril among others, is a tricyclic antidepressant (TCA) used widely throughout Europe for the treatment of depression. It has similar efficacy and effects relative to other TCAs like imipramine but with fewer side effects.
Key facts
- Drug.legal_status
- Rx-only
- Drug.width
- 190
- Drug.Verifiedfields
- changed
- Drug.verifiedrevid
- 447436237
- Drug.IUPAC_name
- 10-(2-(dimethylamino)ethyl)-5-methyl-5H-dibenzo[b,e][1,4]diazepin-11(10H)-one
- Drug.image
- Dibenzepin Structural Formula V1.svg
- Drug.image_class
- skin-invert-image
- Drug.alt
- Skeletal formula of dibenzepin
- Drug.image2
- Dibenzepin 3D spacefill.png
- Drug.image_class2
- bg-transparent
- Drug.alt2
- Space-filling model of the dibenzepin molecule
- Drug.tradename
- Noveril, Anslopax, Deprex, Ecatril, Neodit, Victoril
- Drug.legal_BR
- C1
- Drug.routes_of_administration
- Oral
- Drug.bioavailability
- 25%
- Drug.protein_bound
- 80%
- Drug.metabolism
- Hepatic
- Drug.elimination_half life
- 5 hours
via Wikipedia infobox
Chemical data
- Formula
- C18H21N3O
- Molecular weight
- 295.4 g/mol
- IUPAC name
- 5-[2-(dimethylamino)ethyl]-11-methylbenzo[b][1,4]benzodiazepin-6-one
- SMILES
- CN1C2=CC=CC=C2C(=O)N(C3=CC=CC=C31)CCN(C)C
- InChIKey
- QPGGEKPRGVJKQB-UHFFFAOYSA-N
- XLogP
- 2.7
- Polar surface area
- 26.8 Ų
- H-bond donors
- 0
- H-bond acceptors
- 3
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
Withdrawn- Max clinical phase
- Approved
- Molecule type
- Small molecule
- Indications
- major depressive disorder
via ChEMBL · EBI
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 295.168
Show 6 more facts
- Commons category
- Dibenzepin
- chemical formula
- C₁₈H₂₁N₃O
- canonical SMILES
- CN1C2=CC=CC=C2C(=O)N(C3=CC=CC=C31)CCN(C)C
- subject has role
- tricyclic antidepressant
- medical condition treated
- depression
- World Health Organisation international non-proprietary name
- dibenzepin
via Wikidata · CC0
~3 min read
Encyclopedic overview
10 sectionsContents
- Medical uses
- Overdose
- Pharmacology
- Pharmacodynamics
- Pharmacokinetics
- History
- Society and culture
- Brand names
- References
- External links
Dibenzepin, sold under the brand name Noveril among others, is a tricyclic antidepressant (TCA) used widely throughout Europe for the treatment of depression. It has similar efficacy and effects relative to other TCAs like imipramine but with fewer side effects.
==Medical uses== Dibenzepin is used mainly in the treatment of major depressive disorder.
Excerpted from Wikipedia’s “dibenzepin” article, available under the CC BY-SA 4.0 licence.