二氫可待因

Also known as DF-118, Dicogesic®, dihydrocodeine bitartrate, Drocode, Paracodeine®, Dihydrocodeine, DHC, Remedacen

Dihydrocodeine is a semi-synthetic opioid analgesic prescribed for pain or severe dyspnea, or as an antitussive, either alone or compounded with paracetamol (acetaminophen) (as in co-dydramol) or aspirin. It was developed in Germany in 1908 and first marketed in 1911.

In the Vinony graph

Vinony's link graph records 962 inbound references to 二氫可待因, and connects out to antitussive, chlorpheniramine and (+)-catechin.

It sits within the topics 4,5-Epoxymorphinans, Catechol ethers and Cleanup tagged articles with a reason field from August 2014.

Vinony links it to 25 Wikipedia language editions.

Chemical data

Formula: C18H23NO3
Molecular weight: 301.4 g/mol
IUPAC name: (4R,4aR,7S,7aR,12bS)-9-methoxy-3-methyl-2,4,4a,5,6,7,7a,13-octahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-ol
SMILES: CN1CC[C@]23[C@@H]4[C@H]1CC5=C2C(=C(C=C5)OC)O[C@H]3[C@H](CC4)O
InChIKey: RBOXVHNMENFORY-DNJOTXNNSA-N
XLogP: 2.2
Polar surface area: 41.9 Å²
H-bond donors: 1
H-bond acceptors: 4
Formal charge: 0

via PubChem

Drug data · ChEMBL

Max clinical phase: Approved
Molecule type: Small molecule
First approval: 1983
Admin. routes: oral
Indications: pain

via ChEMBL · EBI

Research

544 papers

via PubMed

Wikidata facts

Has part: oxygen
Mass: 301.168
Has use: medication

Show 9 more facts

found in taxon: Papaver somniferum
defined daily dose: 0.15
significant drug interaction: primidone
chemical formula: C₁₈H₂₃NO₃
medical condition treated: cough
Commons category: Dihydrocodeine
isomeric SMILES: CN1CC[C@]23[C@@H]4[C@H]1CC5=C2C(=C(C=C5)OC)O[C@H]3[C@H](CC4)O
canonical SMILES: CN1CCC23C4C1CC5=C2C(=C(C=C5)OC)OC3C(CC4)O
subject has role: opioid