Flunisolide

Key facts

Drug.Verifiedfields

changed

Drug.verifiedrevid

461101454

Drug.IUPAC_name

(1S,2S,4R,8S,9S,11S,12S,13R,19S)-19-fluoro-11-hydroxy-8-(2-hydroxyacetyl)-6,6,9,13-tetramethyl-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icosa-14,17-dien-16-one

Drug.image

Flunisolide.png

Drug.image_class

skin-invert-image

Drug.image2

Flunisolide ball-and-stick.png

Drug.image_class2

bg-transparent

Drug.tradename

Aerobid, Nasalide, Nasarel, others

Drug.MedlinePlus

a681048

Drug.routes_of_administration

Inhaled

Drug.protein_bound

40% after inhalation

Drug.elimination_half life

1.8 hours

Drug.IUPHAR_ligand

7076

Drug.CAS_number

3385-03-3

Drug.ATC_prefix

R01

Drug.ATC_suffix

AD04

Drug.PubChem

82153

Drug.DrugBank

DB00180

via Wikipedia infobox

Chemical data

Formula

C24H31FO6

Molecular weight

434.5 g/mol

IUPAC name

(1S,2S,4R,8S,9S,11S,12S,13R,19S)-19-fluoro-11-hydroxy-8-(2-hydroxyacetyl)-6,6,9,13-tetramethyl-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icosa-14,17-dien-16-one

SMILES

C[C@]12C[C@@H]([C@H]3[C@H]([C@@H]1C[C@@H]4[C@]2(OC(O4)(C)C)C(=O)CO)C[C@@H](C5=CC(=O)C=C[C@]35C)F)O

InChIKey

XSFJVAJPIHIPKU-XWCQMRHXSA-N

XLogP

2.5

Polar surface area

93.1 Ų

H-bond donors

2

H-bond acceptors

7

Formal charge

0

via PubChem

Drug data · ChEMBL

Max clinical phase

Approved

Molecule type

Small molecule

First approval

1981

Admin. routes

topical

Indications

Airway obstruction, Nasal congestion, Rhinitis, Allergic, Perennial, rhinitis

via ChEMBL · EBI

Wikidata facts

Mass

434.21

Has use

medication

via Wikidata · CC0