Structure via PubChem · Public domain (PubChem)
fospropofol
Sign in to saveAlso known as Lusedra®
Fospropofol (INN), often used as the disodium salt (trade name Lusedra), is an intravenous sedative-hypnotic agent. It is currently approved for use in sedation of adult patients undergoing diagnostic or therapeutic procedures such as endoscopy.
Chemical data
- Formula
- C13H21O5P
- Molecular weight
- 288.28 g/mol
- IUPAC name
- [2,6-di(propan-2-yl)phenoxy]methyl dihydrogen phosphate
- SMILES
- CC(C)C1=C(C(=CC=C1)C(C)C)OCOP(=O)(O)O
- InChIKey
- QVNNONOFASOXQV-UHFFFAOYSA-N
- XLogP
- 2.5
- Polar surface area
- 76 Ų
- H-bond donors
- 2
- H-bond acceptors
- 5
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 2008
- Admin. routes
- parenteral
- Indications
- coronary artery disease, atrial fibrillation, hypertension, injury
via ChEMBL · EBI
Research
123 papers- Fospropofol.2006
- Fospropofol.Drugs · 2010
- Fospropofol and remimazolam.International anesthesiology clinics · 2015
- Fospropofol disodium versus propofol for long-term sedation during invasive mechanical ventilation: A pilot randomized clinical trial.Journal of clinical anesthesia · 2024
- Fospropofol disodium for sedation.Drugs of today (Barcelona, Spain : 1998) · 2009
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 288.113
- Has use
- medication
Show 2 more facts
- canonical SMILES
- CC(C)C1=C(C(=CC=C1)C(C)C)OCOP(=O)(O)O
- chemical formula
- C₁₃H₂₁O₅P
Sources (2)
via Wikidata · CC0
~3 min read
Encyclopedic overview
10 sectionsContents
- Clinical applications
- Clinical pharmacology
- Mechanism of action
- Pharmacodynamics
- Pharmacokinetics
- Distribution
- Metabolism
- Controlled substance
- See also
- References
Fospropofol (INN), often used as the disodium salt (trade name Lusedra), is an intravenous sedative-hypnotic agent. It is currently approved for use in sedation of adult patients undergoing diagnostic or therapeutic procedures such as endoscopy.
==Clinical applications== Several water-soluble derivatives and prodrugs of the widely used intravenous anesthetic agent propofol have been developed, of which fospropofol has been found to be the most suitable for clinical development thus far. Purported advantages of this water-soluble chemical compound include less pain at the site of intravenous administration, less potential for hyperlipidemia with long-term administration, and less chance for bacteremia. Often, fospropofol is administered in conjunction with an opioid such as fentanyl.
Excerpted from Wikipedia’s “fospropofol” article, available under the CC BY-SA 4.0 licence.