Structure via PubChem · Public domain (PubChem)
trofosfamide
Sign in to saveTrofosfamide (INN) is a nitrogen mustard alkylating agent. It is sometimes abbreviated "TRO". It has been used in trials to study its effects on ependymoma, medulloblastoma, sarcoma, soft tissue, supratentorial PNET, and recurrent brain tumors.
In the Vinony graph
Vinony's link graph records 271 inbound references to trofosfamide, and connects out to tiazofurin, medication and digital object identifier.
Vinony files it under Chemical pages without DrugBank identifier, Chloroethyl compounds and Drugboxes which contain changes to verified fields.
Vinony links it to 8 Wikipedia language editions.
Chemical data
- Formula
- C9H18Cl3N2O2P
- Molecular weight
- 323.6 g/mol
- IUPAC name
- N,N,3-tris(2-chloroethyl)-2-oxo-1,3,2lambda5-oxazaphosphinan-2-amine
- SMILES
- C1CN(P(=O)(OC1)N(CCCl)CCCl)CCCl
- InChIKey
- UMKFEPPTGMDVMI-UHFFFAOYSA-N
- XLogP
- 1.8
- Polar surface area
- 32.8 Ų
- H-bond donors
- 0
- H-bond acceptors
- 4
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 3
- Molecule type
- Small molecule
- Indications
- sarcoma, melanoma, medulloblastoma, soft tissue sarcoma
via ChEMBL · EBI
Research
166 papers- Feasibility and tolerability of trofosfamide and etoposide in progressive glioblastoma.Neuro-oncology advances · 2023
- Trofosfamide in the palliative treatment of cancer: a review of the literature.Onkologie · 2004
- Trofosfamide in the treatment of elderly or frail patients with diffuse large B-cell lymphoma.Journal of cancer research and clinical oncology · 2019
- Trofosfamide: a review of its pharmacodynamic and pharmacokinetic properties and therapeutic potential in the oral treatment of cancer.Anti-cancer drugs · 1997
- Genetic effects of cyclophosphamide, ifosfamide and trofosfamide.Mutation research · 1976
via PubMed
Wikidata facts
- Subclass of
- medication
- Has part
- carbon
- Mass
- 322.017
Show 4 more facts
- chemical formula
- C₉H₁₈Cl₃N₂O₂P
- canonical SMILES
- C1CN(P(=O)(OC1)N(CCCl)CCCl)CCCl
- subject has role
- immunosuppressive drug
- Commons category
- Trofosfamide
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
1 sectionsContents
- References
Trofosfamide (INN) is a nitrogen mustard alkylating agent. It is sometimes abbreviated "TRO". It has been used in trials to study its effects on ependymoma, medulloblastoma, sarcoma, soft tissue, supratentorial PNET, and recurrent brain tumors.
==References==
Excerpted from Wikipedia’s “trofosfamide” article, available under the CC BY-SA 4.0 licence.
Available in 8 languages
via Wikidata sitelinks · CC0