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GeneQ18027188· pop 5· linked from 816 articles

HOXC8

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Also known as HOX3, HOX3A, homeobox C8

Homeobox protein Hox-C8 is a protein that in humans is encoded by the HOXC8 gene.

In the Vinony graph

Vinony's link graph records 816 inbound references to HOXC8, and connects out to PubMed, human chromosome 12 and homeobox.

Vinony files it under Genes on human chromosome 12 and Transcription factors.

Vinony links it to 5 Wikipedia language editions.

Gene data

HOXC8

Name: homeobox C8
Type: protein-coding
Position: 54,008,911–54,012,769 (+)
Aliases: HOX3, HOX3A
Ensembl: ENSG00000037965
RefSeq RNA: NM_022658.4, XM_054371921.1, XM_054371922.1
RefSeq protein: NP_073149.1, XP_054227896.1, XP_054227897.1

This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. The product of this gene may play a role in the regulation of cartilage differentiation. It could also be involved in chondrodysplasias or other cartilage disorders. [provided by RefSeq, Jul 2008].

Gene Ontology

Biological process

regulation of DNA-templated transcription regulation of transcription by RNA polymerase II

Molecular function

RNA polymerase II transcription regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA binding DNA-binding transcription factor activity protein binding sequence-specific double-stranded DNA binding

Cellular component

chromatin nucleus nucleus nucleoplasm nucleoplasm

Pathways

Cell-Cell communication Cell-Cell communication Adherens junctions interactions Adherens junctions interactions Cell-cell junction organization Cell-cell junction organization Cell junction organization Cell junction organization Regulation of CDH11 Expression and Function Regulation of CDH11 Expression and Function

via MyGene.info

Gene · Ensembl

homeobox C8

Symbol: HOXC8
Biotype: Protein coding
Organism: Homo sapiens
Location: 12:54,008,911-54,012,769
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene

Show 7 more facts

HomoloGene ID: 130642
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/3224
genomic end: 54012769
genomic start: 54008985
chromosome: human chromosome 12
cytogenetic location: 12q13.13

Sources (4)

via Wikidata · CC0

~1 min read

Encyclopedic overview

6 sections

Contents

Function
See also
Interactions
References
Further reading
External links

Homeobox protein Hox-C8 is a protein that in humans is encoded by the HOXC8 gene.

== Function ==

Excerpted from Wikipedia’s “HOXC8” article, available under the CC BY-SA 4.0 licence.

Available in 5 languages

via Wikidata sitelinks · CC0

Categories

Genes on human chromosome 12 Transcription factors