HTR3A
Sign in to saveAlso known as 5-HT-3, 5-HT3A, 5-HT3R, 5HT3R, HTR3, 5-hydroxytryptamine receptor 3A
5-hydroxytryptamine receptor 3A is a protein that in humans is encoded by the HTR3A gene.
In the Vinony graph
Within Vinony's link graph, HTR3A is referenced by 99 other articles, and connects out to PubMed, Ensembl genome database project and cell surface receptor.
It sits within the topics Genes on human chromosome 11, Ion channels and Serotonin receptors.
Its subject is documented across 6 Wikipedia language editions.
Gene data
HTR3A- Name
- 5-hydroxytryptamine receptor 3A
- Type
- protein-coding
- Aliases
- 5-HT-3, 5-HT3A, 5-HT3R, 5HT3R, HTR3
The product of this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit A of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor causes fast, depolarizing responses in neurons after activation. It appears that the heteromeric combination of A and B subunits is necessary to provide the full functional features of this receptor, since either subunit alone results in receptors with very low conductance and response amplitude. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008].
via MyGene.info
Gene · Ensembl
5-hydroxytryptamine receptor 3A
- Symbol
- HTR3A
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 11:113,975,075-113,990,313
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 8 more facts
- HomoloGene ID
- 671
- genomic end
- 113990313
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/3359
- genomic start
- 113975075
- cytogenetic location
- 11q23.2
- chromosome
- human chromosome 11
- Commons category
- HTR3A
Sources (3)
via Wikidata · CC0
~1 min read
Encyclopedic overview
4 sectionsContents
- See also
- References
- Further reading
- External links
5-hydroxytryptamine receptor 3A is a protein that in humans is encoded by the HTR3A gene.
The product of this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit A of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor causes fast, depolarizing responses in neurons after activation. The A subunit is the only one that can be expressed alone and forms homomers with a very low single channel conductance of 0.6pS. When combined with the B subunit and expressed as a heteromer, the single channel conductance increases immensely. Alternatively spliced transcript variants encoding different isoforms have been identified.
Excerpted from Wikipedia’s “HTR3A” article, available under the CC BY-SA 4.0 licence.