IL18BP
Sign in to saveAlso known as IL18BPa, interleukin 18 binding protein, FVH
Interleukin-18-binding protein is a protein that in humans is encoded by the IL18BP gene.
In the Vinony graph
Vinony's link graph records 159 inbound references to IL18BP, and connects out to PubMed, human chromosome 11 and Interleukin 2.
It is catalogued under the topic Genes on human chromosome 11.
Vinony links it to 5 Wikipedia language editions.
Gene data
IL18BP- Name
- interleukin 18 binding protein
- Type
- protein-coding
- Position
- 71,998,613–72,007,315 (+)
- Aliases
- FVH, IL18BPa
- Ensembl
- ENSG00000137496
- RefSeq RNA
- NM_001039659.2, NM_001039660.2, NM_001145055.1, NM_001145057.1, NM_005699.3
- RefSeq protein
- NP_001034748.1, NP_001034749.1, NP_001138527.1, NP_001138529.1, NP_005690.2
The protein encoded by this gene functions as an inhibitor of the proinflammatory cytokine, IL18. It binds IL18, prevents the binding of IL18 to its receptor, and thus inhibits IL18-induced IFN-gamma production, resulting in reduced T-helper type 1 immune responses. This protein is constitutively expressed and secreted in mononuclear cells. Elevated level of this protein is detected in the intestinal tissues of patients with Crohn's disease. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
interleukin 18 binding protein
- Symbol
- IL18BP
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 11:71,998,613-72,007,315
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 7 more facts
- HomoloGene ID
- 7781
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/10068
- genomic end
- 71716761
- genomic start
- 71998613
- chromosome
- human chromosome 11
- cytogenetic location
- 11q13.4
Sources (3)
via Wikidata · CC0
~1 min read
Encyclopedic overview
3 sectionsContents
- References
- Further reading
- External links
Interleukin-18-binding protein is a protein that in humans is encoded by the IL18BP gene.
The protein encoded by this gene is an inhibitor of the proinflammatory cytokine IL18. This protein binds to IL18, prevents the binding of IL18 to its receptor, and thus inhibits IL18-induced IFN-gamma production. This protein is constitutively expressed and secreted in mononuclear cells. The expression of this protein can be enhanced by IFN-gamma. An elevated level of this protein is detected in the intestinal tissues of patients with Crohn's disease. Three transcript variants encoding the same protein have been found for this gene.
Excerpted from Wikipedia’s “IL18BP” article, available under the CC BY-SA 4.0 licence.