ADAM18
Sign in to saveAlso known as ADAM27, tMDCIII, ADAM metallopeptidase domain 18
Disintegrin and metalloproteinase domain-containing protein 18 is an enzyme that in humans is encoded by the ADAM18 gene.
In the Vinony graph
Vinony's link graph records 143 inbound references to ADAM18, and connects out to PubMed, human chromosome 8 and Ensembl genome database project.
It is catalogued under topics including EC 3.4.24, Genes on human chromosome 8 and Human proteins.
Vinony links it to 4 Wikipedia language editions.
Gene data
ADAM18- Name
- ADAM metallopeptidase domain 18
- Type
- protein-coding
- Position
- 39,584,489–39,730,065 (+)
- Aliases
- ADAM27, tMDCIII
- Ensembl
- ENSG00000278548
- RefSeq RNA
- NM_001190956.2, NM_001320313.2, NM_014237.3, NR_135201.2
- RefSeq protein
- NP_001177885.1, NP_001307242.1, NP_055052.1
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The encoded preproprotein is proteolytically processed to generate the mature sperm surface protein. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016].
Gene Ontology
Biological process
Molecular function
Cellular component
via MyGene.info
Gene · Ensembl
ADAM metallopeptidase domain 18
- Symbol
- ADAM18
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 8:39,584,489-39,730,065
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 10 more facts
- HomoloGene ID
- 74941
- genetic association
- HIV infection
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/8749
- chromosome
- human chromosome 8
- genomic start
- 39442008
- genomic end
- 39730065
- cytogenetic location
- 8p11.22
- expressed in
- urinary bladder
- Commons category
- ADAM18
via Wikidata · CC0
~1 min read
Encyclopedic overview
3 sectionsContents
- References
- Further reading
- External links
Disintegrin and metalloproteinase domain-containing protein 18 is an enzyme that in humans is encoded by the ADAM18 gene.
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene is a sperm surface protein.
Excerpted from Wikipedia’s “ADAM18” article, available under the CC BY-SA 4.0 licence.