Structure via PubChem · Public domain (PubChem)
Indinavir
Sign in to saveAlso known as L-735524, MK-639, IDV, (1(1S,2R),5(S))-2,3,5-trideoxy-N-(2,3-dihydro-2-hydroxy-1H-inden-1-yl)-5-(2-(((1,1-dimethylethyl)amino)carbonyl)-4-(3-pyridinylmethyl)-1-piperazinyl)-2-(phenylmethyl)-D-erythro-pentonamide, indinavir anhydrous
compuesto químico
Chemical data
- Formula
- C36H47N5O4
- Molecular weight
- 613.8 g/mol
- IUPAC name
- (2S)-1-[(2S,4R)-4-benzyl-2-hydroxy-5-[[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]amino]-5-oxopentyl]-N-tert-butyl-4-(pyridin-3-ylmethyl)piperazine-2-carboxamide
- SMILES
- CC(C)(C)NC(=O)[C@@H]1CN(CCN1C[C@H](C[C@@H](CC2=CC=CC=C2)C(=O)N[C@@H]3[C@@H](CC4=CC=CC=C34)O)O)CC5=CN=CC=C5
- InChIKey
- CBVCZFGXHXORBI-PXQQMZJSSA-N
- XLogP
- 2.8
- Polar surface area
- 118 Ų
- H-bond donors
- 4
- H-bond acceptors
- 7
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 1996
- Admin. routes
- oral
via ChEMBL · EBI
Research
2,833 papers- Indinavir urolithiasis.Current opinion in urology · 2000
- Indinavir crystalluria.Kidney international · 2006
- Indinavir: a review of its use in the management of HIV infection.Drugs · 1999
- Optimizing indinavir regimens.HIV medicine · 2000
- Indinavir-related alopecia.AIDS (London, England) · 1998
via PubMed
Wikidata facts
- Subclass of
- protease inhibitor
- Mass
- 613.363
- Has use
- medication
Show 12 more facts
- chemical formula
- C₃₆H₄₇N₅O₄
- significant drug interaction
- rifapentine
- World Health Organisation international non-proprietary name
- indinavir
- medical condition treated
- HIV infection
- canonical SMILES
- CC(C)(C)NC(=O)C1CN(CCN1CC(CC(CC2=CC=CC=C2)C(=O)NC3C(CC4=CC=CC=C34)O)O)CC5=CN=CC=C5
- isomeric SMILES
- CC(C)(C)NC(=O)[C@@H]1CN(CCN1C[C@H](C[C@@H](CC2=CC=CC=C2)C(=O)N[C@@H]3[C@@H](CC4=CC=CC=C34)O)O)CC5=CN=CC=C5
- defined daily dose
- 2.4
- Commons category
- Indinavir
- subject has role
- essential medicine
- found in taxon
- Streptomyces
- short name
- IDV
- different from
- IDV
Sources (7)
via Wikidata · CC0
Article · Español
El indinavir es un antirretroviral del grupo de los inhibidores enzimáticos de la proteasa; y es utilizado en la terapia antirretroviral altamente supresiva de pacientes con infección por VIH. Este medicamento fue aprobado por la FDA el 13 de marzo de 1996, haciendo el octavo en su tipo en ser aprobado.
Abstract from DBpedia / Wikipedia · CC BY-SA