İndinavir

Also known as L-735524, MK-639, IDV, (1(1S,2R),5(S))-2,3,5-trideoxy-N-(2,3-dihydro-2-hydroxy-1H-inden-1-yl)-5-(2-(((1,1-dimethylethyl)amino)carbonyl)-4-(3-pyridinylmethyl)-1-piperazinyl)-2-(phenylmethyl)-D-erythro-pentonamide, indinavir anhydrous

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In the Vinony graph

Vinony's link graph records 506 inbound references to İndinavir, and connects out to tenofovir alafenamide, antiretroviral therapy for HIV/AIDS and United States Food and Drug Administration.

It is catalogued under topics including 2-Pyridyl compounds, Carboxamides and CYP3A4 inhibitors.

Vinony links it to 24 Wikipedia language editions.

Chemical data

Formula: C36H47N5O4
Molecular weight: 613.8 g/mol
IUPAC name: (2S)-1-[(2S,4R)-4-benzyl-2-hydroxy-5-[[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]amino]-5-oxopentyl]-N-tert-butyl-4-(pyridin-3-ylmethyl)piperazine-2-carboxamide
SMILES: CC(C)(C)NC(=O)[C@@H]1CN(CCN1C[C@H](C[C@@H](CC2=CC=CC=C2)C(=O)N[C@@H]3[C@@H](CC4=CC=CC=C34)O)O)CC5=CN=CC=C5
InChIKey: CBVCZFGXHXORBI-PXQQMZJSSA-N
XLogP: 2.8
Polar surface area: 118 Å²
H-bond donors: 4
H-bond acceptors: 7
Formal charge: 0

via PubChem

Drug data · ChEMBL

Max clinical phase: Approved
Molecule type: Small molecule
First approval: 1996
Admin. routes: oral

via ChEMBL · EBI

Research

2,833 papers

Indinavir urolithiasis.Current opinion in urology · 2000
Indinavir crystalluria.Kidney international · 2006
Indinavir: a review of its use in the management of HIV infection.Drugs · 1999
Optimizing indinavir regimens.HIV medicine · 2000
Indinavir-related alopecia.AIDS (London, England) · 1998

via PubMed

Wikidata facts

Subclass of: protease inhibitor
Mass: 613.363
Has use: medication

Show 12 more facts

chemical formula: C₃₆H₄₇N₅O₄
significant drug interaction: rifapentine
World Health Organisation international non-proprietary name: indinavir
medical condition treated: HIV infection
canonical SMILES: CC(C)(C)NC(=O)C1CN(CCN1CC(CC(CC2=CC=CC=C2)C(=O)NC3C(CC4=CC=CC=C34)O)O)CC5=CN=CC=C5
isomeric SMILES: CC(C)(C)NC(=O)[C@@H]1CN(CCN1C[C@H](C[C@@H](CC2=CC=CC=C2)C(=O)N[C@@H]3[C@@H](CC4=CC=CC=C34)O)O)CC5=CN=CC=C5
defined daily dose: 2.4
Commons category: Indinavir
subject has role: essential medicine
found in taxon: Streptomyces
short name: IDV
different from: IDV