อินดินาเวียร์

Also known as L-735524, MK-639, IDV, (1(1S,2R),5(S))-2,3,5-trideoxy-N-(2,3-dihydro-2-hydroxy-1H-inden-1-yl)-5-(2-(((1,1-dimethylethyl)amino)carbonyl)-4-(3-pyridinylmethyl)-1-piperazinyl)-2-(phenylmethyl)-D-erythro-pentonamide, indinavir anhydrous

Indinavir (IDV; trade name Crixivan, made by Merck) is a protease inhibitor used as a component of highly active antiretroviral therapy to treat HIV/AIDS. It is soluble white powder administered orally in combination with other antiviral drugs. The drug prevents protease from functioning normally. Consequently, HIV viruses cannot reproduce, causing a decrease in the viral load. Commercially sold indinavir is indinavir anhydrous, which is indinavir with an additional amine in the hydroxyethylene backbone. This enhances its solubility and oral bioavailability, making it easier for users to intak

In the Vinony graph

Within Vinony's link graph, อินดินาเวียร์ is referenced by 506 other articles, and connects out to tenofovir alafenamide, antiretroviral therapy for HIV/AIDS and United States Food and Drug Administration.

It sits within the topics 2-Pyridyl compounds, Carboxamides and CYP3A4 inhibitors.

Its subject is documented across 24 Wikipedia language editions.

Chemical data

Formula: C36H47N5O4
Molecular weight: 613.8 g/mol
IUPAC name: (2S)-1-[(2S,4R)-4-benzyl-2-hydroxy-5-[[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]amino]-5-oxopentyl]-N-tert-butyl-4-(pyridin-3-ylmethyl)piperazine-2-carboxamide
SMILES: CC(C)(C)NC(=O)[C@@H]1CN(CCN1C[C@H](C[C@@H](CC2=CC=CC=C2)C(=O)N[C@@H]3[C@@H](CC4=CC=CC=C34)O)O)CC5=CN=CC=C5
InChIKey: CBVCZFGXHXORBI-PXQQMZJSSA-N
XLogP: 2.8
Polar surface area: 118 Å²
H-bond donors: 4
H-bond acceptors: 7
Formal charge: 0

via PubChem

Drug data · ChEMBL

Max clinical phase: Approved
Molecule type: Small molecule
First approval: 1996
Admin. routes: oral

via ChEMBL · EBI

Research

2,833 papers

Indinavir urolithiasis.Current opinion in urology · 2000
Indinavir crystalluria.Kidney international · 2006
Indinavir: a review of its use in the management of HIV infection.Drugs · 1999
Optimizing indinavir regimens.HIV medicine · 2000
Indinavir-related alopecia.AIDS (London, England) · 1998

via PubMed

Wikidata facts

Subclass of: protease inhibitor
Mass: 613.363
Has use: medication

Show 12 more facts

chemical formula: C₃₆H₄₇N₅O₄
significant drug interaction: rifapentine
World Health Organisation international non-proprietary name: indinavir
medical condition treated: HIV infection
canonical SMILES: CC(C)(C)NC(=O)C1CN(CCN1CC(CC(CC2=CC=CC=C2)C(=O)NC3C(CC4=CC=CC=C34)O)O)CC5=CN=CC=C5
isomeric SMILES: CC(C)(C)NC(=O)[C@@H]1CN(CCN1C[C@H](C[C@@H](CC2=CC=CC=C2)C(=O)N[C@@H]3[C@@H](CC4=CC=CC=C34)O)O)CC5=CN=CC=C5
defined daily dose: 2.4
Commons category: Indinavir
subject has role: essential medicine
found in taxon: Streptomyces
short name: IDV
different from: IDV