Structure via PubChem · Public domain (PubChem)
インジナビル
Sign in to saveAlso known as L-735524, MK-639, IDV, (1(1S,2R),5(S))-2,3,5-trideoxy-N-(2,3-dihydro-2-hydroxy-1H-inden-1-yl)-5-(2-(((1,1-dimethylethyl)amino)carbonyl)-4-(3-pyridinylmethyl)-1-piperazinyl)-2-(phenylmethyl)-D-erythro-pentonamide, indinavir anhydrous
抗ウイルス薬の一つ
Chemical data
- Formula
- C36H47N5O4
- Molecular weight
- 613.8 g/mol
- IUPAC name
- (2S)-1-[(2S,4R)-4-benzyl-2-hydroxy-5-[[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]amino]-5-oxopentyl]-N-tert-butyl-4-(pyridin-3-ylmethyl)piperazine-2-carboxamide
- SMILES
- CC(C)(C)NC(=O)[C@@H]1CN(CCN1C[C@H](C[C@@H](CC2=CC=CC=C2)C(=O)N[C@@H]3[C@@H](CC4=CC=CC=C34)O)O)CC5=CN=CC=C5
- InChIKey
- CBVCZFGXHXORBI-PXQQMZJSSA-N
- XLogP
- 2.8
- Polar surface area
- 118 Ų
- H-bond donors
- 4
- H-bond acceptors
- 7
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 1996
- Admin. routes
- oral
via ChEMBL · EBI
Research
2,833 papers- Indinavir urolithiasis.Current opinion in urology · 2000
- Indinavir crystalluria.Kidney international · 2006
- Indinavir: a review of its use in the management of HIV infection.Drugs · 1999
- Optimizing indinavir regimens.HIV medicine · 2000
- Indinavir-related alopecia.AIDS (London, England) · 1998
via PubMed
Wikidata facts
- Subclass of
- protease inhibitor
- Mass
- 613.363
- Has use
- medication
Show 12 more facts
- chemical formula
- C₃₆H₄₇N₅O₄
- significant drug interaction
- rifapentine
- World Health Organisation international non-proprietary name
- indinavir
- medical condition treated
- HIV infection
- canonical SMILES
- CC(C)(C)NC(=O)C1CN(CCN1CC(CC(CC2=CC=CC=C2)C(=O)NC3C(CC4=CC=CC=C34)O)O)CC5=CN=CC=C5
- isomeric SMILES
- CC(C)(C)NC(=O)[C@@H]1CN(CCN1C[C@H](C[C@@H](CC2=CC=CC=C2)C(=O)N[C@@H]3[C@@H](CC4=CC=CC=C34)O)O)CC5=CN=CC=C5
- defined daily dose
- 2.4
- Commons category
- Indinavir
- subject has role
- essential medicine
- found in taxon
- Streptomyces
- short name
- IDV
- different from
- IDV
Sources (7)
via Wikidata · CC0
Article · 日本語
インジナビル（Indinavir、IDV）はプロテアーゼ阻害剤で、HIV感染症や後天性免疫不全症候群（AIDS）を治療するための抗ウイルス療法（anti retroviral therapy：ART。以前は highly active anti-retroviral therapy：HAARTと呼ばれた）で使用される。商標名はクリキシバン(Crixivan)で、メルク社によって生産されている。
Abstract from DBpedia / Wikipedia · CC BY-SA