KRT81
Sign in to saveAlso known as HB1, Hb-1, KRTHB1, MLN137, ghHkb1, hHAKB2-1, keratin 81, K81
Keratin, type II cuticular Hb1 is a protein that in humans is encoded by the KRT81 gene.
In the Vinony graph
Within Vinony's link graph, KRT81 is referenced by 328 other articles, and connects out to hair keratin, PubMed and human chromosome 12.
It is catalogued under the topic Genes on human chromosome 12.
Its subject is documented across 5 Wikipedia language editions.
Gene data
KRT81- Name
- keratin 81
- Type
- protein-coding
- Position
- 52,285,913–52,291,534 (−)
- Aliases
- HB1, Hb-1, K81, KRTHB1, MLN137, MNLIX2, ghHkb1, hHAKB2-1, hHb1
- Ensembl
- ENSG00000205426
- RefSeq RNA
- NM_002281.4, NR_190103.1
- RefSeq protein
- NP_002272.2
The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5. All hair keratins are expressed in the hair follicle; this hair keratin, as well as KRTHB3 and KRTHB6, is found primarily in the hair cortex. Mutations in this gene and KRTHB6 have been observed in patients with a rare dominant hair disease, monilethrix. Some human genome assemblies (example T2T-CHM13) have a non-coding version of the gene due to the presence of a SNP that introduces a premature stop codon after codon 281. [provided by RefSeq, Jan 2024].
Gene Ontology
Biological process
Molecular function
Cellular component
via MyGene.info
Gene · Ensembl
keratin 81
- Symbol
- KRT81
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 12:52,285,913-52,291,534
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 9 more facts
- HomoloGene ID
- 55645
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/3887
- genomic end
- 52685318
- genomic start
- 52679697
- chromosome
- human chromosome 12
- cytogenetic location
- 12q13.13
- genetic association
- monilethrix
- expressed in
- bone
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- References
- Further reading
Keratin, type II cuticular Hb1 is a protein that in humans is encoded by the KRT81 gene.
The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5. All hair keratins are expressed in the hair follicle; this hair keratin, as well as KRTHB3 and KRTHB6, is found primarily in the hair cortex. Mutations in this gene and KRTHB6 have been observed in patients with a rare dominant hair disease, monilethrix.
Excerpted from Wikipedia’s “KRT81” article, available under the CC BY-SA 4.0 licence.