KRT81
Sign in to saveAlso known as HB1, Hb-1, KRTHB1, MLN137, ghHkb1, hHAKB2-1, keratin 81, K81
Keratin, type II cuticular Hb1 is a protein that in humans is encoded by the KRT81 gene.
Gene data
KRT81- Name
- keratin 81
- Type
- protein-coding
- Aliases
- HB1, Hb-1, K81, KRTHB1, MLN137, MNLIX2, ghHkb1, hHAKB2-1
The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5. All hair keratins are expressed in the hair follicle; this hair keratin, as well as KRTHB3 and KRTHB6, is found primarily in the hair cortex. Mutations in this gene and KRTHB6 have been observed in patients with a rare dominant hair disease, monilethrix. Some human genome assemblies (example T2T-CHM13) have a non-coding version of the gene due to the presence of a SNP that introduces a premature stop codon after codon 281. [provided by RefSeq, Jan 2024].
via MyGene.info
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 55645
- exact match
- identifiers.org/ncbigene/3887
- genomic end
- 52685318
- genomic start
- 52679697
- cytogenetic location
- 12q13.13
Sources (4)
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Keratin, type II cuticular Hb1 is a protein that in humans is encoded by the KRT81 gene.
The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5. All hair keratins are expressed in the hair follicle; this hair keratin, as well as KRTHB3 and KRTHB6, is found primarily in the hair cortex. Mutations in this gene and KRTHB6 have been observed in patients with a rare dominant hair disease, monilethrix.