Structure via PubChem · Public domain (PubChem)
levocabastine
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Levocabastine (trade name Livostin or Livocab, depending on the region) is a selective second-generation H1 receptor antagonist which was discovered at Janssen Pharmaceutica in 1979. It is used for allergic conjunctivitis.
Chemical data
- Formula
- C26H29FN2O2
- Molecular weight
- 420.5 g/mol
- IUPAC name
- (3S,4R)-1-[4-cyano-4-(4-fluorophenyl)cyclohexyl]-3-methyl-4-phenylpiperidine-4-carboxylic acid
- SMILES
- C[C@@H]1CN(CC[C@@]1(C2=CC=CC=C2)C(=O)O)C3CCC(CC3)(C#N)C4=CC=C(C=C4)F
- InChIKey
- ZCGOMHNNNFPNMX-YHYDXASRSA-N
- XLogP
- 2.5
- Polar surface area
- 64.3 Ų
- H-bond donors
- 1
- H-bond acceptors
- 5
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 1993
- Admin. routes
- topical
- Indications
- eye allergy, Nasal congestion, seasonal allergic rhinitis, Rhinitis, Allergic, Perennial
via ChEMBL · EBI
Research
323 papers- Levocabastine.2006
- Levocabastine: an effective topical treatment of allergic rhinoconjunctivitis.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 1991
- Levocabastine. An update of its pharmacology, clinical efficacy and tolerability in the topical treatment of allergic rhinitis and conjunctivitis.Drugs · 1995
- Levocabastine eye drops: a new approach for the treatment of acute allergic conjunctivitis.European journal of ophthalmology · 1994
- Levocabastine. A review of its pharmacological properties and therapeutic potential as a topical antihistamine in allergic rhinitis and conjunctivitis.Drugs · 1991
via PubMed
Wikidata facts
- Mass
- 420.2213
- Has use
- medication
Show 7 more facts
- chemical formula
- C₂₆H₂₉FN₂O₂
- NCI Thesaurus ID
- C61806
- World Health Organisation international non-proprietary name
- levocabastine
- canonical SMILES
- N#CC1(CCC(CC1)N2CCC(C(C2)C)(C(=O)O)C3=CC=CC=C3)C4=CC=C(C=C4)F
- defined daily dose
- 0.6
- isomeric SMILES
- C[C@@H]1CN(CC[C@]1(C(O)=O)C2=CC=CC=C2)[C@H]3CC[C@](CC3)(C#N)C4=CC=C(F)C=C4
- Commons category
- Levocabastine
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- References
- External links
Levocabastine (trade name Livostin or Livocab, depending on the region) is a selective second-generation H1 receptor antagonist which was discovered at Janssen Pharmaceutica in 1979. It is used for allergic conjunctivitis.
As well as acting as an antihistamine, levocabastine has also subsequently been found to act as a potent and selective antagonist for the neurotensin receptor NTS2, and was the first drug used to characterise the different neurotensin subtypes. This has made it a useful tool for the study of this receptor.
Excerpted from Wikipedia’s “levocabastine” article, available under the CC BY-SA 4.0 licence.
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via Wikidata sitelinks · CC0