Structure via PubChem · Public domain (PubChem)
Lisuride
Sign in to saveAlso known as (+)-lisuride, Dopergin®, lysuride, N'-((8alpha)-9,10-Didehydro-6-methylergolin-8-yl)-N,N-diethylurea, Lisuridum, Lisurid, Lisurida
farmaco
Chemical data
- Formula
- C20H26N4O
- Molecular weight
- 338.4 g/mol
- IUPAC name
- 3-[(6aR,9S)-7-methyl-6,6a,8,9-tetrahydro-4H-indolo[4,3-fg]quinolin-9-yl]-1,1-diethylurea
- SMILES
- CCN(CC)C(=O)N[C@@H]1CN([C@@H]2CC3=CNC4=CC=CC(=C34)C2=C1)C
- InChIKey
- BKRGVLQUQGGVSM-KBXCAEBGSA-N
- XLogP
- 2.7
- Polar surface area
- 51.4 Ų
- H-bond donors
- 2
- H-bond acceptors
- 2
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 3
- Molecule type
- Small molecule
- Indications
- cocaine dependence, restless legs syndrome, Parkinson disease, migraine disorder
via ChEMBL · EBI
Research
1,030 papers- Are the LSD-analogs lisuride and ergotamine examples of non-hallucinogenic serotonin 5-HT2A receptor agonists?Journal of psychopharmacology (Oxford, England) · 2025
- Lisuride for levodopa-induced complications in Parkinson's disease.The Cochrane database of systematic reviews · 2000
- Lisuride in parkinsonism.Annals of neurology · 1981
- Lisuride, a dopamine receptor agonist with 5-HT2B receptor antagonist properties: absence of cardiac valvulopathy adverse drug reaction reports supports the concept of a crucial role for 5-HT2B receptor agonism in cardiac valvular fibrosis.Clinical neuropharmacology · 2006
- Lisuride versus bromocriptine for levodopa-induced complications in Parkinson's disease.The Cochrane database of systematic reviews · 2000
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 338.210661
- Has use
- medication
Show 7 more facts
- subject has role
- serotonin receptor agonists
- isomeric SMILES
- CCN(CC)C(=O)N[C@@H]1CN([C@@H]2CC3=CNC4=CC=CC(=C34)C2=C1)C
- canonical SMILES
- CCN(CC)C(=O)NC1CN(C2CC3=CNC4=CC=CC(=C34)C2=C1)C
- chemical formula
- C₂₀H₂₆N₄O
- defined daily dose
- 0.6
- World Health Organisation international non-proprietary name
- lisuride
- Commons category
- Lisuride
via Wikidata · CC0
Article · Italiano
Lisuride è farmaco utilizzato nel trattamento della malattia di Parkinson che agisce come agonista dei recettori della dopamina e agonista parziale di numerosi recettori serotoninergici e del recettore H1. Il farmaco trova impiego anche nel trattamento preventivo per gli attacchi emicranici e per ridurre i livelli ematici di prolattina.
Abstract from DBpedia / Wikipedia · CC BY-SA