Memantin

Also known as 3,5-dimethyl-1-adamantanamine, 1,3-dimethyl-5-adamantanamine, 3,5-dimethyl-1-aminoadamantane, 3,5-dimethyltricyclo[3.3.1.1(3,7)]decan-1-amine, 1-amino-3,5-dimethyladamantane, 1,3-dimethylaminoadamantane

Gruppe von Stereoisomeren

In the Vinony graph

Within Vinony's link graph, Memantin is referenced by 2,852 other articles, and connects out to agonist, nicotinic acetylcholine receptor and NMDA receptor.

It sits within the topics 5-HT3 antagonists, Adamantanes and Amines.

Its subject is documented across 34 Wikipedia language editions.

Chemical data

Formula: C12H21N
Molecular weight: 179.3 g/mol
IUPAC name: 3,5-dimethyladamantan-1-amine
SMILES: CC12CC3CC(C1)(CC(C3)(C2)N)C
InChIKey: BUGYDGFZZOZRHP-UHFFFAOYSA-N
XLogP: 3.3
Polar surface area: 26 Å²
H-bond donors: 1
H-bond acceptors: 1
Formal charge: 0

via PubChem

Drug data · ChEMBL

Max clinical phase: Approved
Molecule type: Small molecule
First approval: 2002
Admin. routes: oral
Indications: autism spectrum disorder, nicotine dependence, autism, pain

via ChEMBL · EBI

Research

5,145 papers

Mechanism of action of memantine.Current opinion in pharmacology · 2006
Cholinesterase inhibitors and memantine for the treatment of Alzheimer and non-Alzheimer dementias.Ideggyogyaszati szemle · 2021
Memantine.Drugs & aging · 2003
Memantine: Updating a rare success story in pro-cognitive therapeutics.Neuropharmacology · 2024
Memantine Derivatives as Multitarget Agents in Alzheimer's Disease.Molecules (Basel, Switzerland) · 2020

via PubMed

Described at

Memantine: a medicine to treat some types of dementia. - NHS

NHS medicines information on memantine – what it's used for, side effects, dosage and who can take it.

nhs.uk →

Link to a page describing this subject · 2,355 chars · not written by Vinony

Wikidata facts

Has part: carbon
Mass: 179.1674
Has use: medication

Show 8 more facts

Commons category: Memantine
medical condition treated: Alzheimer's disease
chemical formula: C₁₂H₂₁N
canonical SMILES: CC12CC3CC(C1)(CC(C3)(C2)N)C
World Health Organisation international non-proprietary name: memantine
defined daily dose: 40
subject has role: dopaminergic
described at URL: www.healthline.com/health/drugs/memantine-oral-tablet

Sources (7)

via Wikidata · CC0

Article · Deutsch

Memantin ist ein Derivat des Amantadins und wird zur Behandlung von moderaten bis schweren Demenz-Formen vom Alzheimer-Typ eingesetzt. Es ist der einzige Vertreter der Klasse der NMDA-Rezeptor-Antagonisten (NMDA = N-Methyl-D-Aspartat) bei den Antialzheimer-Medikamenten. Seine Wirksamkeit wird allerdings kontrovers diskutiert.

Abstract from DBpedia / Wikipedia · CC BY-SA