Structure via PubChem · Public domain (PubChem)
мемантин
Sign in to saveAlso known as 3,5-dimethyl-1-adamantanamine, 1,3-dimethyl-5-adamantanamine, 3,5-dimethyl-1-aminoadamantane, 3,5-dimethyltricyclo[3.3.1.1(3,7)]decan-1-amine, 1-amino-3,5-dimethyladamantane, 1,3-dimethylaminoadamantane
группа стереоизомеров
In the Vinony graph
Within Vinony's link graph, мемантин is referenced by 2,852 other articles, and connects out to agonist, nicotinic acetylcholine receptor and NMDA receptor.
It sits within the topics 5-HT3 antagonists, Adamantanes and Amines.
Its subject is documented across 34 Wikipedia language editions.
Chemical data
- Formula
- C12H21N
- Molecular weight
- 179.3 g/mol
- IUPAC name
- 3,5-dimethyladamantan-1-amine
- SMILES
- CC12CC3CC(C1)(CC(C3)(C2)N)C
- InChIKey
- BUGYDGFZZOZRHP-UHFFFAOYSA-N
- XLogP
- 3.3
- Polar surface area
- 26 Ų
- H-bond donors
- 1
- H-bond acceptors
- 1
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 2002
- Admin. routes
- oral
- Indications
- autism spectrum disorder, nicotine dependence, autism, pain
via ChEMBL · EBI
Research
5,145 papers- Mechanism of action of memantine.Current opinion in pharmacology · 2006
- Cholinesterase inhibitors and memantine for the treatment of Alzheimer and non-Alzheimer dementias.Ideggyogyaszati szemle · 2021
- Memantine.Drugs & aging · 2003
- Memantine: Updating a rare success story in pro-cognitive therapeutics.Neuropharmacology · 2024
- Memantine Derivatives as Multitarget Agents in Alzheimer's Disease.Molecules (Basel, Switzerland) · 2020
via PubMed
Described at
Memantine: a medicine to treat some types of dementia. - NHS
NHS medicines information on memantine – what it's used for, side effects, dosage and who can take it.
nhs.uk →Link to a page describing this subject · 2,355 chars · not written by Vinony
Wikidata facts
- Has part
- carbon
- Mass
- 179.1674
- Has use
- medication
Show 8 more facts
- Commons category
- Memantine
- medical condition treated
- Alzheimer's disease
- chemical formula
- C₁₂H₂₁N
- canonical SMILES
- CC12CC3CC(C1)(CC(C3)(C2)N)C
- World Health Organisation international non-proprietary name
- memantine
- defined daily dose
- 40
- subject has role
- dopaminergic
- described at URL
- www.healthline.com/health/drugs/memantine-oral-tablet
Sources (7)
via Wikidata · CC0
Article · Русский
Мемантин — NMDA-антагонист, используемый в терапии болезни Альцгеймера (БА), но также проходящий клинические испытания в качестве возможной терапии ряда других состояний, в их числе СДВГ, ВИЧ-ассоциированная деменция, нистагм, рассеянный склероз. Мемантин входит в перечень жизненно необходимых и важнейших лекарственных препаратов РФ. В 2018 году мемантин исключён из французского перечня финансируемых правительством лекарств из-за отсутствия доказательств его эффективности.
Abstract from DBpedia / Wikipedia · CC BY-SA