naratriptan

Also known as Amerge®, GR-85548A, N-methyl-2-[3-(1-methyl-4-piperidyl)-1H-indol-5-yl]-ethanesulfonamide, N-methyl-2-(3-(1-methylpiperiden-4-yl)indole-5-yl)ethanesulfonamide, N-Methyl-2-(3-(1-methylpiperiden-4-yl)indole-5-yl)ethanesulfonamide, Naratriptanum,

Chemical data

Formula: C17H25N3O2S
Molecular weight: 335.5 g/mol
IUPAC name: N-methyl-2-[3-(1-methylpiperidin-4-yl)-1H-indol-5-yl]ethanesulfonamide
SMILES: CNS(=O)(=O)CCC1=CC2=C(C=C1)NC=C2C3CCN(CC3)C
InChIKey: AMKVXSZCKVJAGH-UHFFFAOYSA-N
XLogP: 2
Polar surface area: 73.6 Å²
H-bond donors: 2
H-bond acceptors: 4
Formal charge: 0

via PubChem

Research

364 papers

~5 min read

Article

10 sections

Contents

Medical uses
Efficacy
Side effects
Pharmacology
Mechanism of action
Chemistry
History
Society and culture
See also
References

Naratriptan, sold under the brand names Amerge and Naramig among others, is a triptan drug marketed by GlaxoSmithKline and is used for the treatment of migraine headaches. It is a selective serotonin 5-HT1 receptor family agonist.

It was patented in 1987 and approved for medical use in 1997.