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nimesulide
Sign in to saveAlso known as R-805
Nimesulide is a nonsteroidal anti-inflammatory drug (NSAID) with pain medication and fever reducing properties. Its approved indications are the treatment of acute pain, the symptomatic treatment of osteoarthritis, and primary dysmenorrhoea in adolescents and adults above 12 years old.
Chemical data
- Formula
- C13H12N2O5S
- Molecular weight
- 308.31 g/mol
- IUPAC name
- N-(4-nitro-2-phenoxyphenyl)methanesulfonamide
- SMILES
- CS(=O)(=O)NC1=C(C=C(C=C1)[N+](=O)[O-])OC2=CC=CC=C2
- InChIKey
- HYWYRSMBCFDLJT-UHFFFAOYSA-N
- XLogP
- 2.6
- Polar surface area
- 110 Ų
- H-bond donors
- 1
- H-bond acceptors
- 6
- Formal charge
- 0
via PubChem
Research
1,915 papersvia PubMed
~9 min read
Encyclopedic overview
17 sectionsContents
- Medical uses
- Children
- Pregnancy and lactation
- Available forms
- Contraindications
- Side effects
- Pharmacology
- Pharmacodynamics
- Pharmacokinetics
- History
- Society and culture
- Brand names
- India
- EMA confirms the positive benefit/risk ratio
- Irish Medicines Board
- Bribes
- References
Nimesulide is a nonsteroidal anti-inflammatory drug (NSAID) with pain medication and fever reducing properties. Its approved indications are the treatment of acute pain, the symptomatic treatment of osteoarthritis, and primary dysmenorrhoea in adolescents and adults above 12 years old.
Side effects may include liver problems. It has a multifactorial mode of action and is characterized by a fast onset of action. It works by blocking the production of prostaglandins (a chemical associated with pain), thereby relieving pain and inflammation.
Excerpted from Wikipedia’s “nimesulide” article, available under the CC BY-SA 4.0 licence.