اگزاتومید

Also known as Oxatomide

Oxatomide, sold under the brand name Tinset among others, is a antihistamine of the diphenylmethylpiperazine family which is marketed in Europe, Japan, and a number of other countries. It was discovered at Janssen Pharmaceutica in 1975. Oxatomide lacks any anticholinergic effects. In addition to its H1 receptor antagonism, it also possesses antiserotonergic activity similarly to hydroxyzine. Oxatomide was also found to have antiviral activity against Venezuelan equine encephalitis virus (VEEV).

Chemical data

Formula: C27H30N4O
Molecular weight: 426.6 g/mol
IUPAC name: 3-[3-(4-benzhydrylpiperazin-1-yl)propyl]-1H-benzimidazol-2-one
SMILES: C1CN(CCN1CCCN2C3=CC=CC=C3NC2=O)C(C4=CC=CC=C4)C5=CC=CC=C5
InChIKey: BAINIUMDFURPJM-UHFFFAOYSA-N
XLogP: 4.1
Polar surface area: 38.8 Å²
H-bond donors: 1
H-bond acceptors: 3
Formal charge: 0

via PubChem

Drug data · ChEMBL

Max clinical phase: Phase 2
Molecule type: Small molecule
Indications: allergic disease, Duchenne muscular dystrophy

via ChEMBL · EBI

Research

248 papers

Oxatomide for stable asthma in adults and children.The Cochrane database of systematic reviews · 2003
Oxatomide. A review of its pharmacodynamic properties and therapeutic efficacy.Drugs · 1984
Antiinflammatory effects of oxatomide.Journal of investigational allergology & clinical immunology · 1999
[Oxatomide: review of pharmacodynamic effects and clinical effects in dermatology].Allergie et immunologie · 1990
[Protective effect of oxatomide in infantile bronchial asthma. Double-blind study vs placebo].Minerva pediatrica · 1998

via PubMed

Wikidata facts

Subclass of: chemical compound
Mass: 426.242

Show 4 more facts

chemical formula: C₂₇H₃₀N₄O
canonical SMILES: C1CN(CCN1CCCN2C3=CC=CC=C3NC2=O)C(C4=CC=CC=C4)C5=CC=CC=C5
Commons category: Oxatomide
defined daily dose: 60

Sources (3)

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Gallery (2)

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