PHOX2A
Sign in to saveAlso known as ARIX, CFEOM2, FEOM2, NCAM2, PMX2A, paired like homeobox 2a
Paired mesoderm homeobox protein 2A is a protein that in humans is encoded by the PHOX2A gene.
In the Vinony graph
Vinony's link graph records 815 inbound references to PHOX2A, and connects out to PubMed, human chromosome 11 and Ensembl genome database project.
It is catalogued under topics including Genes on human chromosome 11 and Transcription factors.
Vinony links it to 5 Wikipedia language editions.
Gene data
PHOX2A- Name
- paired like homeobox 2A
- Type
- protein-coding
- Position
- 72,239,077–72,245,664 (−)
- Aliases
- ARIX, CFEOM2, FEOM2, PMX2A
- Ensembl
- ENSG00000165462
- RefSeq RNA
- NM_001425096.1, NM_001425097.1, NM_001425098.1, NM_005169.4
- RefSeq protein
- NP_001412025.1, NP_001412026.1, NP_001412027.1, NP_005160.2
The protein encoded by this gene contains a paired-like homeodomain most similar to that of the Drosophila aristaless gene product. The encoded protein plays a central role in development of the autonomic nervous system. It regulates the expression of tyrosine hydroxylase and dopamine beta-hydroxylase, two catecholaminergic biosynthetic enzymes essential for the differentiation and maintenance of the noradrenergic neurotransmitter phenotype. The encoded protein has also been shown to regulate transcription of the alpha3 nicotinic acetylcholine receptor gene. Mutations in this gene have been associated with autosomal recessive congenital fibrosis of the extraocular muscles. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Cellular component
via MyGene.info
Gene · Ensembl
paired like homeobox 2A
- Symbol
- PHOX2A
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 11:72,239,077-72,245,664
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 8 more facts
- HomoloGene ID
- 31296
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/401
- genomic end
- 71956708
- genomic start
- 71950121
- chromosome
- human chromosome 11
- cytogenetic location
- 11q13.4
- expressed in
- muscle tissue
Sources (3)
via Wikidata · CC0
~1 min read
Encyclopedic overview
6 sectionsContents
- Function
- Interactions
- See also
- References
- Further reading
- External links
Paired mesoderm homeobox protein 2A is a protein that in humans is encoded by the PHOX2A gene.
== Function ==
Excerpted from Wikipedia’s “PHOX2A” article, available under the CC BY-SA 4.0 licence.