propiram
Sign in to savePropiram (Algeril, Dirame, Bay 4503) is a partial μ-opioid receptor agonist and weak μ antagonist analgesic from the ampromide family of drugs related to other drugs such as phenampromide and diampromide. It was invented in 1963 in the United Kingdom by Bayer but was not widely marketed, although it saw some limited clinical use, especially in dentistry. Propiram reached Phase III clinical trials in the United States and Canada.
Wikidata facts
- Mass
- 275.2
Show 4 more facts
- chemical formula
- C₁₆H₂₅N₃O
- canonical SMILES
- CCC(=O)N(C1=CC=CC=N1)C(C)CN2CCCCC2
- MCN code
- 2933.33.92
- Commons category
- Propiram
Sources (2)
via Wikidata · CC0
~2 min read
Article
4 sectionsContents
- Pharmacology
- Derivatives
- Regulation
- References
Propiram (Algeril, Dirame, Bay 4503) is a partial μ-opioid receptor agonist and weak μ antagonist analgesic from the ampromide family of drugs related to other drugs such as phenampromide and diampromide. It was invented in 1963 in the United Kingdom by Bayer but was not widely marketed, although it saw some limited clinical use, especially in dentistry. Propiram reached Phase III clinical trials in the United States and Canada.
==Pharmacology== Propiram exhibits weak opioid antagonist activity on the μ receptor—quite a bit weaker than its agonist effects—and the effect on κ- and δ-opioid, σ-receptors, or the NMDA system are not well understood. Other drugs of the partial μ-opioid agonist/antagonist type include meptazinol, buprenorphine, butorphanol, phenazocine, nalbuphine, pentazocine, dezocine and its relatives.
Available in 8 languages
via Wikidata sitelinks · CC0