proquazone

Chemical data

Formula

C18H18N2O

Molecular weight

278.3 g/mol

IUPAC name

7-methyl-4-phenyl-1-propan-2-ylquinazolin-2-one

SMILES

CC1=CC2=C(C=C1)C(=NC(=O)N2C(C)C)C3=CC=CC=C3

InChIKey

JTIGKVIOEQASGT-UHFFFAOYSA-N

XLogP

3

Polar surface area

32.7 Ų

H-bond donors

0

H-bond acceptors

1

Formal charge

0

via PubChem

Drug data · ChEMBL

Max clinical phase

Phase 2

Molecule type

Small molecule

Indications

rheumatic disease

via ChEMBL · EBI

• Proquazone. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in rheumatic diseases and pain states.Drugs · 1987
• Pharmacokinetics of the antirheumatic proquazone in healthy humans.Journal of pharmaceutical sciences · 1984
• Proquazone (Biarison) and indomethacin (Indocid) in the treatment of ankylosing spondylitis. Two comparative, clinical, double-blind studies.Scandinavian journal of rheumatology. Supplement · 1978
• A comparative, double-blind trial with proquazone and naproxen in the treatment of rheumatoid arthritis.Scandinavian journal of rheumatology. Supplement · 1978
• A long-term double-blind comparative study on proquazone (Biarison) and ibuprofen in rheumatoid arthritis.Scandinavian journal of rheumatology. Supplement · 1978

via PubMed

Wikidata facts

Subclass of

chemical compound

Mass

278.142

via Wikidata · CC0