protriptyline
Sign in to saveAlso known as MK-240, N-methyl-5H-dibenzo[a,d]cycloheptene-5-propylamine, 7-(3-methylaminopropyl)-1,2:5,6-dibenzocycloheptatriene, 5-(3-methylaminopropyl)-5H-dibenzo[a,d]cycloheptene, amimetilina, 3-(5H-dibenzo[a,d]cyclohepten-5-yl)-N-methyl-1-propanamine, N-methyl-5H-dibenzo[a,d]cycloheptene-5-propanamine
Protriptyline, sold under the brand name Vivactil among others, is a tricyclic antidepressant (TCA), specifically a secondary amine. Uniquely among most of the TCAs, protriptyline tends to be energizing instead of sedating, and is sometimes used for narcolepsy to achieve a wakefulness-promoting effect.
Key facts
- Drug.ChEMBL
- 668
- Drug.excretion
- Urine: 50%Feces: minor
- Drug.verifiedrevid
- 464375600
- Drug.IUPAC_name
- 3-(5H-dibenzo[a,d][7]annulen-5-yl)-N-methylpropan-1-amine
- Drug.image
- Protriptyline.svg
- Drug.image_class
- skin-invert-image
- Drug.width
- 200px
- Drug.caption
- Above: molecular structure of protriptyline Below: 3D representation of a protriptyline molecule
- Drug.image2
- Protripyline 3D.png
- Drug.image_class2
- bg-transparent
- Drug.tradename
- Vivactyl, others
- Drug.MedlinePlus
- a604025
- Drug.pregnancy_US
- C
- Drug.legal_BR
- C1
- Drug.legal_status
- Rx-only
- Drug.routes_of_administration
- Oral
- Drug.bioavailability
- 77–93%
- Drug.protein_bound
- 92%
via Wikipedia infobox
Research
420 papers- Protriptyline.2006
- Protriptyline.2012
- Protriptyline.2026
- Protriptyline kinetics.Clinical pharmacology and therapeutics · 1978
- Protriptyline, a tricyclic antidepressant, inhibits voltage-dependent K+ channels in rabbit coronary arterial smooth muscle cells.Acta biochimica et biophysica Sinica · 2020
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 263.1674
- Has use
- medication
Show 8 more facts
- chemical formula
- C₁₉H₂₁N
- significant drug interaction
- tranylcypromine
- World Health Organisation international non-proprietary name
- protriptyline
- canonical SMILES
- CNCCCC1C2=CC=CC=C2C=CC3=CC=CC=C13
- subject has role
- tricyclic antidepressant
- defined daily dose
- 30
- physically interacts with
- solute carrier family 6 member 4
- Commons category
- Protriptyline
Sources (3)
via Wikidata · CC0
~15 min read
Encyclopedic overview
18 sectionsContents
- Medical uses
- Contraindications
- Side effects
- Withdrawal
- List of side effects
- Overdose
- Interactions
- Pharmacology
- Pharmacodynamics
- Pharmacokinetics
- Chemistry
- History
- Society and culture
- Generic names
- Brand names
- Availability
- See also
- References
Protriptyline, sold under the brand name Vivactil among others, is a tricyclic antidepressant (TCA), specifically a secondary amine. Uniquely among most of the TCAs, protriptyline tends to be energizing instead of sedating, and is sometimes used for narcolepsy to achieve a wakefulness-promoting effect.
TCAs including protriptyline are also used to reduce the incidence of recurring headaches such as migraine, and for other types of chronic pain.
Excerpted from Wikipedia’s “protriptyline” article, available under the CC BY-SA 4.0 licence.