普罗替林

Also known as MK-240, N-methyl-5H-dibenzo[a,d]cycloheptene-5-propylamine, 7-(3-methylaminopropyl)-1,2:5,6-dibenzocycloheptatriene, 5-(3-methylaminopropyl)-5H-dibenzo[a,d]cycloheptene, amimetilina, 3-(5H-dibenzo[a,d]cyclohepten-5-yl)-N-methyl-1-propanamine, N-methyl-5H-dibenzo[a,d]cycloheptene-5-propanamine

化合物

In the Vinony graph

Within Vinony's link graph, 普罗替林 is referenced by 1,108 other articles, and connects out to histamine antagonist, propranolol and adrenergic receptor.

It is catalogued under topics including Alpha-1 blockers, Antihistamines and Dibenzocycloheptenes.

Its subject is documented across 14 Wikipedia language editions.

Key facts

Drug.ChEMBL: 668
Drug.excretion: Urine: 50%Feces: minor
Drug.verifiedrevid: 464375600
Drug.IUPAC_name: 3-(5H-dibenzo[a,d][7]annulen-5-yl)-N-methylpropan-1-amine
Drug.image: Protriptyline.svg
Drug.image_class: skin-invert-image
Drug.width: 200px
Drug.caption: Above: molecular structure of protriptyline Below: 3D representation of a protriptyline molecule
Drug.image2: Protripyline 3D.png
Drug.image_class2: bg-transparent
Drug.tradename: Vivactyl, others
Drug.MedlinePlus: a604025
Drug.pregnancy_US: C
Drug.legal_BR: C1
Drug.legal_status: Rx-only
Drug.routes_of_administration: Oral
Drug.bioavailability: 77–93%
Drug.protein_bound: 92%

via Wikipedia infobox

Chemical data

Formula: C19H21N
Molecular weight: 263.4 g/mol
IUPAC name: N-methyl-3-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,9,11,13-heptaenyl)propan-1-amine
SMILES: CNCCCC1C2=CC=CC=C2C=CC3=CC=CC=C13
InChIKey: BWPIARFWQZKAIA-UHFFFAOYSA-N
XLogP: 4.4
Polar surface area: 12 Å²
H-bond donors: 1
H-bond acceptors: 1
Formal charge: 0