Structure via PubChem · Public domain (PubChem)
quifenadine
Sign in to saveQuifenadine (, trade name: Fenkarol, Фенкарол) is a 2nd generation antihistamine drug, marketed mainly in post-Soviet countries. Chemically, it is a quinuclidine derivative.
Chemical data
- Formula
- C20H23NO
- Molecular weight
- 293.4 g/mol
- IUPAC name
- 1-azabicyclo[2.2.2]octan-3-yl(diphenyl)methanol
- SMILES
- C1CN2CCC1C(C2)C(C3=CC=CC=C3)(C4=CC=CC=C4)O
- InChIKey
- PZMAHNDJABQWGS-UHFFFAOYSA-N
- XLogP
- 3.4
- Polar surface area
- 23.5 Ų
- H-bond donors
- 1
- H-bond acceptors
- 2
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
- Indications
- allergic disease
via ChEMBL · EBI
Research
26 papers- The antiarrhythmic properties of quifenadine, H1-histamine receptor blocker in children with premature beats: a randomized controlled pilot trial.American journal of therapeutics · 2010
- [Use of antihistamines in a physician's clinical practice].Terapevticheskii arkhiv · 2014
- [The effect of antihistamine preparations on the contraction of the isolated guinea pig ureter].Farmakologiia i toksikologiia · 1989
- Further developments in research on the chemistry and pharmacology of synthetic quinuclidine derivatives.Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques · 1983
- [Effect of the antihistamine preparation, phencarol, on the central nervous system].Farmakologiia i toksikologiia · 1980
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 293.178
Show 5 more facts
- chemical formula
- C₂₀H₂₃NO
- canonical SMILES
- C1CN2CCC1C(C2)C(C3=CC=CC=C3)(C4=CC=CC=C4)O
- route of administration
- oral administration
- Commons category
- Quifenadine
- subject has role
- histamine antagonist
Sources (2)
via Wikidata · CC0
~2 min read
Encyclopedic overview
4 sectionsContents
- Indications
- Synthesis
- See also
- References
Quifenadine (, trade name: Fenkarol, Фенкарол) is a 2nd generation antihistamine drug, marketed mainly in post-Soviet countries. Chemically, it is a quinuclidine derivative.
The drug has antiarrhythmic properties, probably due to the presence of a quinuclidine nucleus in the molecule's core. It acts as a calcium channel blocker and influences the activity of potassium channels. In children with cardiac arrhythmia, combination therapy with quifenadone and either amiodarone or propafenone was found to be more effective than monotherapy with either amiodarone or propafenone.
Excerpted from Wikipedia’s “quifenadine” article, available under the CC BY-SA 4.0 licence.
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