ramipril

Also known as HOE-498, Tritace, (2S-(1(R*(R*)),2alpha,3abeta,6abeta))-1-(2-((1-(Ethoxycarbonyl)-3-phenylpropyl)amino)-1-oxopropyl)octahydrocyclopenta(b)pyrrole-2-carboxylic acid, Altace (TN), Ramiprilum, Ramicor,

Chemical data

Formula: C23H32N2O5
Molecular weight: 416.5 g/mol
IUPAC name: (2S,3aS,6aS)-1-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]-3,3a,4,5,6,6a-hexahydro-2H-cyclopenta[b]pyrrole-2-carboxylic acid
SMILES: CCOC(=O)[C@H](CCC1=CC=CC=C1)N[C@@H](C)C(=O)N2[C@H]3CCC[C@H]3C[C@H]2C(=O)O
InChIKey: HDACQVRGBOVJII-JBDAPHQKSA-N
XLogP: 1.4
Polar surface area: 95.9 Å²
H-bond donors: 2
H-bond acceptors: 6
Formal charge: 0

via PubChem

Research

3,199 papers

~7 min read

Article

11 sections

Contents

Activation and binding
Medical uses
Contraindications
Adverse effects
Mechanism of action
Synthesis
Society and culture
US patent
Brand names
Research
References

Ramipril, sold under the brand name Altace among others, is an ACE inhibitor type medication used to treat high blood pressure, heart failure, and diabetic kidney disease. It can also be used as a preventative medication in patients over 55 years old to reduce the risk of having a heart attack, stroke or cardiovascular death in patients shown to be at high risk, such as some diabetics and patients with vascular disease. It is a reasonable initial treatment for high blood pressure. It is taken by mouth.

Common side effects include headaches, dizziness, fatigue, and cough. Serious side effects may include liver problems, angioedema, kidney problems, and high blood potassium. Use in pregnancy and breastfeeding is not recommended. It is an ACE inhibitor and works by decreasing renin-angiotensin-aldosterone system activity.