RHOC

Also known as ARH9, ARHC, H9, RHOH9, ras homolog family member C

RhoC (Ras homolog gene family, member C) is a small (~21 kDa) signaling G protein (more specifically a GTPase), and is a member of the Rac subfamily of the family Rho family of GTPases. It is encoded by the gene RHOC.

Gene data

RHOC

Name: ras homolog family member C
Type: protein-coding
Position: 112,701,127–112,707,845 (−)
Aliases: ARH9, ARHC, H9, RHOH9
Ensembl: ENSG00000155366
RefSeq RNA: NM_001042678.2, NM_001042679.2, NM_175744.5
RefSeq protein: NP_001036143.1, NP_001036144.1, NP_786886.1

This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The protein encoded by this gene is prenylated at its C-terminus, and localizes to the cytoplasm and plasma membrane. It is thought to be important in cell locomotion. Overexpression of this gene is associated with tumor cell proliferation and metastasis. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008].

Pathways

Developmental Biology Developmental Biology Signal Transduction Signal Transduction Signaling by Rho GTPases Signaling by Rho GTPases RHO GTPase Effectors RHO GTPase Effectors Signaling by GPCR Semaphorin interactions

via MyGene.info

Wikidata facts

Image: Protein RHOC PDB 1a2b.png

Show 6 more facts

HomoloGene ID: 90945
exact match: identifiers.org/ncbigene/389
genomic end: 113250056
genomic start: 112701127
cytogenetic location: 1p13.2
Commons category: RhoC GTP-binding protein

Sources (5)

via Wikidata · CC0

~4 min read

Article

7 sections

Contents

Mechanism and function
Associated signaling pathways
Types of cancer RhoC has been studied in
Potential therapies
References
Further reading
External links

==Mechanism and function== It is prenylated at its C-terminus, and localizes to the cytoplasm and plasma membrane. It is thought to be important in cell locomotion. It cycles between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape and motility. RhoC can activate formins such as mDia1 and FMNL2 to remodel the cytoskeleton.