RHOC
Sign in to saveAlso known as ARH9, ARHC, H9, RHOH9, ras homolog family member C
RhoC (Ras homolog gene family, member C) is a small (~21 kDa) signaling G protein (more specifically a GTPase), and is a member of the Rac subfamily of the family Rho family of GTPases. It is encoded by the gene RHOC.
In the Vinony graph
Within Vinony's link graph, RHOC is referenced by 234 other articles, and connects out to PubMed, Ensembl genome database project and translation elongation factor.
It is catalogued under the topic Genes on human chromosome 1.
Its subject is documented across 5 Wikipedia language editions.
Gene data
RHOC- Name
- ras homolog family member C
- Type
- protein-coding
- Position
- 112,699,765–112,707,897 (−)
- Aliases
- ARH9, ARHC, H9, RHOH9
- Ensembl
- ENSG00000155366
- RefSeq RNA
- NM_001042678.2, NM_001042679.2, NM_175744.5
- RefSeq protein
- NP_001036143.1, NP_001036144.1, NP_786886.1
This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The protein encoded by this gene is prenylated at its C-terminus, and localizes to the cytoplasm and plasma membrane. It is thought to be important in cell locomotion. Overexpression of this gene is associated with tumor cell proliferation and metastasis. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
ras homolog family member C
- Symbol
- RHOC
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 1:112,699,765-112,707,897
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein RHOC PDB 1a2b.png
Show 9 more facts
- HomoloGene ID
- 90945
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/389
- genomic end
- 113250056
- genomic start
- 112701127
- chromosome
- human chromosome 1
- cytogenetic location
- 1p13.2
- Commons category
- RhoC GTP-binding protein
- expressed in
- left coronary artery
via Wikidata · CC0
~4 min read
Encyclopedic overview
7 sectionsContents
- Mechanism and function
- Associated signaling pathways
- Types of cancer RhoC has been studied in
- Potential therapies
- References
- Further reading
- External links
RhoC (Ras homolog gene family, member C) is a small (~21 kDa) signaling G protein (more specifically a GTPase), and is a member of the Rac subfamily of the family Rho family of GTPases. It is encoded by the gene RHOC.
==Mechanism and function== It is prenylated at its C-terminus, and localizes to the cytoplasm and plasma membrane. It is thought to be important in cell locomotion. It cycles between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape and motility. RhoC can activate formins such as mDia1 and FMNL2 to remodel the cytoskeleton.
Excerpted from Wikipedia’s “RHOC” article, available under the CC BY-SA 4.0 licence.