Also known as snRNP, Ribonucleoproteins, Small Nuclear, small nuclear ribonucleoprotein
snRNPs (pronounced "snurps"), or small nuclear ribonucleoproteins, are RNA-protein complexes that combine with unmodified pre-mRNA and various other proteins to form a spliceosome, a large RNA-protein molecular complex upon which splicing of pre-mRNA occurs. The action of snRNPs is essential to the removal of introns from pre-mRNA, a critical aspect of post-transcriptional modification of RNA, occurring only in the nucleus of eukaryotic cells. Additionally, U7 snRNP is not involved in splicing at all, as U7 snRNP is responsible for processing the 3′ stem-loop of histone pre-mRNA.
via PubMed
核小核糖核蛋白(英文:small nuclear ribonucleoproteins,簡稱snRNP)是RNA-蛋白質複合物,與未修飾的mRNA前體(pre-mRNA)和各種其他蛋白質結合形成剪接體,這是一種大型RNA-蛋白質分子復合物,其功能是進行mRNA前體的剪接。snRNP的作用對於從mRNA前體中去除內含子至關重要,是僅發生在真核細胞核中RNA轉錄後修飾的一個關鍵方面。另外,U7 snRNP本身並不參與剪接,因為U7 snRNP負責處理組蛋白mRNA前體的3'莖環。 snRNP的兩個基本組成部分是蛋白質分子和RNA。在每個snRNP顆粒中發現的RNA被稱為小核RNA或snRNA,通常長度約為150個核苷酸。snRNP的snRNA成分通過“識別”內含子5'和3'末端以及分支位點(branch site)的關鍵剪接信號序列來賦予單個內含子特異性。snRNP中的snRNA與核醣體RNA相似,因為它直接結合了酶促作用和結構作用。 SnRNPs是由Michael R. Lerner和Joan A. Steitz發現的。Thomas R. Cech和Sidney Altman在該發現中也有諸多貢獻,由於他們各自獨立發現RNA可以在細胞發育中起催化劑的作用而在1989年獲得諾貝爾化學獎。
Abstract from DBpedia / Wikipedia · CC BY-SA
via Wikidata sitelinks · CC0
Discovered by embedding cosine similarity (sentence-transformers MiniLM, 384-dim).