English

English Deutsch Español Français Italiano Nederlands Português Svenska العربية

GeneQ18031956· pop 5· linked from 814 articles

TFAP4

Sign in to save

Also known as AP-4, bHLHc41, transcription factor AP-4 (activating enhancer binding protein 4), transcription factor AP-4

Transcription factor AP-4 (activating enhancer binding protein 4), also known as TFAP4, is a protein which in humans is encoded by the TFAP4 gene.

In the Vinony graph

Within Vinony's link graph, TFAP4 is referenced by 814 other articles, and connects out to PubMed, human chromosome 16 and homeobox.

Vinony files it under Genes on human chromosome 16 and Transcription factors.

Its subject is documented across 5 Wikipedia language editions.

Gene data

TFAP4

Name: transcription factor AP-4
Type: protein-coding
Position: 4,257,186–4,273,075 (−)
Aliases: AP-4, bHLHc41
Ensembl: ENSG00000090447
RefSeq RNA: NM_003223.3, XM_011522633.4, XM_011522635.4, XM_047434553.1, XM_054313808.1
RefSeq protein: NP_003214.1, XP_011520935.1, XP_011520937.1, XP_047290509.1, XP_054169783.1

Transcription factors of the basic helix-loop-helix-zipper (bHLH-ZIP) family contain a basic domain, which is used for DNA binding, and HLH and ZIP domains, which are used for oligomerization. Transcription factor AP4 activates both viral and cellular genes by binding to the symmetrical DNA sequence CAGCTG (Mermod et al., 1988 [PubMed 2833704]; Hu et al., 1990 [PubMed 2123466]).[supplied by OMIM, Jul 2009].

Gene Ontology

Biological process

regulation of transcription by RNA polymerase II negative regulation of cell population proliferation negative regulation of gene expression DNA damage response, signal transduction by p53 class mediator positive regulation of apoptotic process negative regulation of DNA binding host-mediated suppression of viral transcription host-mediated suppression of viral transcription

Molecular function

transcription cis-regulatory region binding transcription cis-regulatory region binding RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific

Cellular component

chromatin nucleus nucleus nucleus nucleoplasm transcription repressor complex transcription repressor complex

Pathways

Proteoglycans in cancer - Homo sapiens (human)

via MyGene.info

Gene · Ensembl

transcription factor AP-4

Symbol: TFAP4
Biotype: Protein coding
Organism: Homo sapiens
Location: 16:4,257,186-4,273,075
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene

Show 7 more facts

HomoloGene ID: 2424
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/7023
genomic end: 4323076
genomic start: 4307187
chromosome: human chromosome 16
cytogenetic location: 16p13.3

Sources (4)

via Wikidata · CC0

~1 min read

Encyclopedic overview

4 sections

Contents

Function
References
Further reading
External links

Transcription factor AP-4 (activating enhancer binding protein 4), also known as TFAP4, is a protein which in humans is encoded by the TFAP4 gene.

== Function ==

Excerpted from Wikipedia’s “TFAP4” article, available under the CC BY-SA 4.0 licence.

Available in 5 languages

via Wikidata sitelinks · CC0

Categories

Genes on human chromosome 16 Transcription factors