uracil mustard
Also known as U-8344, Uracil Mustard®, uracil nitrogen mustard, aminouracil mustard, 5-(di-2-chloroethyl)aminouracil, 5-[di(beta-chloroethyl)amino]uracil, 5-[bis(2-chloroethyl)amino]-2,4(1H,3H)-pyrimidinedione, 5-[bis(2-chloroethyl)amino]uracil
Uramustine (INN) or uracil mustard is a chemotherapy drug which belongs to the class of alkylating agents. It is used in lymphatic malignancies such as non-Hodgkin's lymphoma. It works by damaging DNA, primarily in cancer cells that preferentially take up the uracil due to their need to make nucleic acids during their rapid cycles of cell division. The DNA damage leads to apoptosis of the affected cells. Bone marrow suppression and nausea are the main side effects.
Chemical data
- Formula
- C8H11Cl2N3O2
- Molecular weight
- 252.09 g/mol
- IUPAC name
- 5-[bis(2-chloroethyl)amino]-1H-pyrimidine-2,4-dione
via PubChem
Research
229 papers- Uracil mustard revisited.Cancer · 1999
- Uracil mustard.IARC monographs on the evaluation of the carcinogenic risk of chemicals to man · 1975
- Uracil mustard in the treatment of thrombocytosis.JAMA · 1980
- Inflammation, Dopaminergic Brain and Bilirubin.International journal of molecular sciences · 2023
- URACIL MUSTARD: A POTENT INDUCER OF LUNG TUMORS IN MICE.Science (New York, N.Y.) · 1965
Article
1 sectionsContents
- References
Uramustine (INN) or uracil mustard is a chemotherapy drug which belongs to the class of alkylating agents. It is used in lymphatic malignancies such as non-Hodgkin's lymphoma. It works by damaging DNA, primarily in cancer cells that preferentially take up the uracil due to their need to make nucleic acids during their rapid cycles of cell division. The DNA damage leads to apoptosis of the affected cells. Bone marrow suppression and nausea are the main side effects.
Chemically it is a derivative of nitrogen mustard and uracil.
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