Structure via PubChem · Public domain (PubChem)
vanoxerine
Sign in to saveAlso known as GBR 12909, GBR12909, 1-{2-[bis(p-fluorophenyl)methoxy]ethyl}-4-(3-phenylpropyl)piperazine
Vanoxerine is an investigational drug which is being evaluated for the treatment of heart arrhythmias and cocaine dependence. Vanoxerine is a piperazine derivative which has multiple pharmacological activities including acting as an dopamine reuptake inhibitor, serotonin transporter inhibitor, and as a blocker of the cardiac hERG repolarizing potassium channel (IKr).
Chemical data
- Formula
- C28H32F2N2O
- Molecular weight
- 450.6 g/mol
- IUPAC name
- 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine
- SMILES
- C1CN(CCN1CCCC2=CC=CC=C2)CCOC(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F
- InChIKey
- NAUWTFJOPJWYOT-UHFFFAOYSA-N
- XLogP
- 5.6
- Polar surface area
- 15.7 Ų
- H-bond donors
- 0
- H-bond acceptors
- 5
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 3
- Molecule type
- Small molecule
- Indications
- atrial fibrillation, atrial flutter, cocaine dependence, cocaine abuse
via ChEMBL · EBI
Research
530 papersvia PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 450.24827
Show 5 more facts
- chemical formula
- C₂₈H₃₂F₂N₂O
- canonical SMILES
- C1CN(CCN1CCCC2=CC=CC=C2)CCOC(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F
- World Health Organisation international non-proprietary name
- vanoxerine
- subject has role
- dopamine reuptake inhibitor
- Commons category
- Vanoxerine
Sources (2)
via Wikidata · CC0
~7 min read
Encyclopedic overview
12 sectionsContents
- Research
- Treatment of cocaine dependence
- Antiarrhythmic
- Miscellaneous
- Pharmacology
- Mechanism of action
- Society and culture
- History
- Chemistry
- Synthesis
- See also
- References
Vanoxerine is an investigational drug which is being evaluated for the treatment of heart arrhythmias and cocaine dependence. Vanoxerine is a piperazine derivative which has multiple pharmacological activities including acting as an dopamine reuptake inhibitor, serotonin transporter inhibitor, and as a blocker of the cardiac hERG repolarizing potassium channel (IKr).
== Research ==
Excerpted from Wikipedia’s “vanoxerine” article, available under the CC BY-SA 4.0 licence.