abt-418
Sign in to saveABT-418 is a drug developed by Abbott, that has nootropic, neuroprotective and anxiolytic effects, and has been researched for treatment of both Alzheimer's disease and ADHD. It acts as an agonist at neural nicotinic acetylcholine receptors, subtype-selective binding with high affinity to the α4β2, α7/5-HT3, and α2β2 nicotinic acetylcholine receptors but not α3β4 receptors ABT-418 was reasonably effective for both applications and fairly well tolerated, but produced some side effects, principally nausea, and it is unclear whether ABT-418 itself will proceed to clinical development or if anothe
Research
77 papers- ABT-418: discriminative stimulus properties and effect on ventral tegmental cell activity.Psychopharmacology · 1995
- Characterization of [3H]ABT-418: a novel cholinergic channel ligand.The Journal of pharmacology and experimental therapeutics · 1995
- Nicotinic acetylcholine receptors and epilepsy.Pharmacological research · 2023
- Central nicotinic receptor agonists ABT-418, ABT-089, and (-)-nicotine reduce distractibility in adult monkeys.Psychopharmacology · 1998
- The enhancement of contextual fear conditioning by ABT-418.Behavioural pharmacology · 2010
via PubMed
Wikidata facts
- Mass
- 166.111
Show 4 more facts
- chemical formula
- C₉H₁₄N₂O
- canonical SMILES
- CC1=NOC(=C1)C2CCCN2C
- isomeric SMILES
- CC1=NOC(=C1)[C@@H]2CCCN2C
- Commons category
- ABT-418
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Article
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- References
ABT-418 is a drug developed by Abbott, that has nootropic, neuroprotective and anxiolytic effects, and has been researched for treatment of both Alzheimer's disease and ADHD. It acts as an agonist at neural nicotinic acetylcholine receptors, subtype-selective binding with high affinity to the α4β2, α7/5-HT3, and α2β2 nicotinic acetylcholine receptors but not α3β4 receptors ABT-418 was reasonably effective for both applications and fairly well tolerated, but produced some side effects, principally nausea, and it is unclear whether ABT-418 itself will proceed to clinical development or if another similar drug will be used instead.
== See also == Epiboxidine Anabaseine