UBE2M
Sign in to saveAlso known as UBC-RS2, UBC12, hUbc12, ubiquitin conjugating enzyme E2 M
NEDD8-conjugating enzyme Ubc12 is a protein that in humans is encoded by the UBE2M gene.
Gene data
UBE2M- Name
- ubiquitin conjugating enzyme E2 M
- Type
- protein-coding
- Aliases
- UBC-RS2, UBC12, hUbc12
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein is linked with a ubiquitin-like protein, NEDD8, which can be conjugated to cellular proteins, such as Cdc53/culin. [provided by RefSeq, Jul 2008].
via MyGene.info
Wikidata facts
- Image
- Protein UBE2M PDB 1y8x.png
Show 5 more facts
- HomoloGene ID
- 2952
- exact match
- identifiers.org/ncbigene/9040
- genomic end
- 58558954
- genomic start
- 59067079
- cytogenetic location
- 19q13.43
Sources (3)
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NEDD8-conjugating enzyme Ubc12 is a protein that in humans is encoded by the UBE2M gene.
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein is linked with a ubiquitin-like protein, NEDD8, which can be conjugated to cellular proteins, such as Cdc53/culin.