ADGRG4
Sign in to saveAlso known as PGR17, RP1-299I16, GPR112, adhesion G protein-coupled receptor G4
G protein-coupled receptor 112 is a protein encoded by the ADGRG4 gene. GPR112 is a member of the adhesion GPCR family. Adhesion GPCRs are characterized by an extended extracellular region often possessing N-terminal protein modules that is linked to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.
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Vinony's link graph records 484 inbound references to ADGRG4, and connects out to PubMed, Ensembl genome database project and protein.
It sits within the topics Genes on human chromosome X and G protein-coupled receptors.
Vinony links it to 5 Wikipedia language editions.
Gene data
ADGRG4- Name
- adhesion G protein-coupled receptor G4
- Type
- protein-coding
- Chromosome
- X
- Position
- 136,300,963–136,416,890 (+)
- Aliases
- GPR112, PGR17, RP1-299I16
- Ensembl
- ENSG00000156920
- RefSeq RNA
- NM_153834.4, XM_011531269.3, XM_011531271.3, XM_047441830.1, XM_047441831.1
- RefSeq protein
- NP_722576.3, XP_011529571.1, XP_011529573.1, XP_047297786.1, XP_047297787.1
This gene encodes a G-protein coupled receptor belonging to a large family of diverse integral membrane proteins that participate in various physiological functions. Members of this superfamily are characterized by a signature 7-transmembrane domain motif. The ligand for this family member is unknown, and it is therefore an orphan receptor. This receptor is known to be expressed in normal enterochromaffin cells and in gastrointestinal neuroendocrine carcinoma cells, and it is therefore considered to be a novel biomarker or target for immunotherapy. [provided by RefSeq, May 2010].
Gene Ontology
Biological process
Molecular function
Cellular component
via MyGene.info
Gene · Ensembl
adhesion G protein-coupled receptor G4
- Symbol
- ADGRG4
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- Chr X:136,300,963-136,416,890
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 7 more facts
- HomoloGene ID
- 72131
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/139378
- chromosome
- human X chromosome
- genomic start
- 135383122
- genomic end
- 136416890
- cytogenetic location
- Xq26.3
Sources (3)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- References
- External links
G protein-coupled receptor 112 is a protein encoded by the ADGRG4 gene. GPR112 is a member of the adhesion GPCR family. Adhesion GPCRs are characterized by an extended extracellular region often possessing N-terminal protein modules that is linked to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.
GPR112 is expressed in human enterochromaffin cells and in the mouse intestine. The N-terminal fragment (NTF) of GPR112 contains pentraxin (PTX)-like modules. GPR112 gene expression has been identified as a marker for neuroendocrine carcinoma cells.
Excerpted from Wikipedia’s “ADGRG4” article, available under the CC BY-SA 4.0 licence.