Structure via PubChem · Public domain (PubChem)
apricoxib
Sign in to saveApricoxib is an experimental anticancer drug and nonsteroidal anti-inflammatory drug (NSAID). It is a COX-2 inhibitor which is intended to improve standard therapy response in molecularly defined models of pancreatic cancer. It was also studied in clinical trials for non-small-cell lung cancer. Development was abandoned in 2015 due to poor clinical trial results.
In the Vinony graph
Vinony's link graph records 279 inbound references to apricoxib, and connects out to clonixin, medication and selenium.
It sits within the topics Abandoned drugs, Cyclooxygenase-2 inhibitors and Drugs missing an ATC code.
Vinony links it to 5 Wikipedia language editions.
Chemical data
- Formula
- C19H20N2O3S
- Molecular weight
- 356.4 g/mol
- IUPAC name
- 4-[2-(4-ethoxyphenyl)-4-methylpyrrol-1-yl]benzenesulfonamide
- SMILES
- CCOC1=CC=C(C=C1)C2=CC(=CN2C3=CC=C(C=C3)S(=O)(=O)N)C
- InChIKey
- JTMITOKKUMVWRT-UHFFFAOYSA-N
- XLogP
- 3.2
- Polar surface area
- 82.7 Ų
- H-bond donors
- 1
- H-bond acceptors
- 4
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
- Indications
- pancreatic carcinoma, non-small cell lung carcinoma, breast cancer, multiple myeloma
via ChEMBL · EBI
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 356.119
Show 5 more facts
- chemical formula
- C₁₉H₂₀N₂O₃S
- canonical SMILES
- CCOC1=CC=C(C=C1)C2=CC(=CN2C3=CC=C(C=C3)S(=O)(=O)N)C
- Commons category
- Apricoxib
- subject has role
- COX-2 inhibitor
- physically interacts with
- Prostaglandin-endoperoxide synthase 2
via Wikidata · CC0
~1 min read
Encyclopedic overview
1 sectionsContents
- References
Apricoxib is an experimental anticancer drug and nonsteroidal anti-inflammatory drug (NSAID). It is a COX-2 inhibitor which is intended to improve standard therapy response in molecularly defined models of pancreatic cancer. It was also studied in clinical trials for non-small-cell lung cancer. Development was abandoned in 2015 due to poor clinical trial results.
== References ==
Excerpted from Wikipedia’s “apricoxib” article, available under the CC BY-SA 4.0 licence.